IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-44197-9.html
   My bibliography  Save this article

Magnaporthe oryzae effector MoSPAB1 directly activates rice Bsr-d1 expression to facilitate pathogenesis

Author

Listed:
  • Ziwei Zhu

    (Sichuan Agricultural University
    Chengdu University)

  • Jun Xiong

    (Sichuan Agricultural University)

  • Hao Shi

    (Sichuan Agricultural University)

  • Yuchen Liu

    (Sichuan Agricultural University)

  • Junjie Yin

    (Sichuan Agricultural University)

  • Kaiwei He

    (Sichuan Agricultural University)

  • Tianyu Zhou

    (Sichuan Agricultural University)

  • Liting Xu

    (Sichuan Agricultural University)

  • Xiaobo Zhu

    (Sichuan Agricultural University)

  • Xiang Lu

    (Sichuan Agricultural University)

  • Yongyan Tang

    (Sichuan Agricultural University)

  • Li Song

    (Sichuan Agricultural University)

  • Qingqing Hou

    (Sichuan Agricultural University)

  • Qing Xiong

    (Sichuan Agricultural University)

  • Long Wang

    (Sichuan Agricultural University)

  • Daihua Ye

    (Sichuan Agricultural University)

  • Tuo Qi

    (Mianyang Teachers’ College)

  • Lijuan Zou

    (Mianyang Teachers’ College)

  • Guobang Li

    (Sichuan Agricultural University)

  • Changhui Sun

    (Sichuan Agricultural University)

  • Zhiyue Wu

    (Sichuan Agricultural University)

  • Peili Li

    (Sichuan Agricultural University)

  • Jiali Liu

    (Sichuan Agricultural University)

  • Yu Bi

    (Sichuan Agricultural University)

  • Yihua Yang

    (Sichuan Agricultural University)

  • Chunxian Jiang

    (Sichuan Agricultural University)

  • Jing Fan

    (Sichuan Agricultural University)

  • Guoshu Gong

    (Sichuan Agricultural University)

  • Min He

    (Sichuan Agricultural University)

  • Jing Wang

    (Sichuan Agricultural University)

  • Xuewei Chen

    (Sichuan Agricultural University)

  • Weitao Li

    (Sichuan Agricultural University)

Abstract

Fungal pathogens typically use secreted effector proteins to suppress host immune activators to facilitate invasion. However, there is rarely evidence supporting the idea that fungal secretory proteins contribute to pathogenesis by transactivating host genes that suppress defense. We previously found that pathogen Magnaporthe oryzae induces rice Bsr-d1 to facilitate infection and hypothesized that a fungal effector mediates this induction. Here, we report that MoSPAB1 secreted by M. oryzae directly binds to the Bsr-d1 promoter to induce its expression, facilitating pathogenesis. Amino acids 103-123 of MoSPAB1 are required for its binding to the Bsr-d1 promoter. Both MoSPAB1 and rice MYBS1 compete for binding to the Bsr-d1 promoter to regulate Bsr-d1 expression. Furthermore, MoSPAB1 homologues are highly conserved among fungi. In particular, Colletotrichum fructicola CfSPAB1 and Colletotrichum sublineola CsSPAB1 activate kiwifruit AcBsr-d1 and sorghum SbBsr-d1 respectively, to facilitate pathogenesis. Taken together, our findings reveal a conserved module that may be widely utilized by fungi to enhance pathogenesis.

Suggested Citation

  • Ziwei Zhu & Jun Xiong & Hao Shi & Yuchen Liu & Junjie Yin & Kaiwei He & Tianyu Zhou & Liting Xu & Xiaobo Zhu & Xiang Lu & Yongyan Tang & Li Song & Qingqing Hou & Qing Xiong & Long Wang & Daihua Ye & T, 2023. "Magnaporthe oryzae effector MoSPAB1 directly activates rice Bsr-d1 expression to facilitate pathogenesis," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-44197-9
    DOI: 10.1038/s41467-023-44197-9
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-44197-9
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-44197-9?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. He Sun & Xinlu Zhu & Chuanxi Li & Zhiming Ma & Xiao Han & Yuanyuan Luo & Liang Yang & Jing Yu & Yansong Miao, 2021. "Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    2. Baihao Zhang & Alexis Vogelzang & Michio Miyajima & Yuki Sugiura & Yibo Wu & Kenji Chamoto & Rei Nakano & Ryusuke Hatae & Rosemary J. Menzies & Kazuhiro Sonomura & Nozomi Hojo & Taisaku Ogawa & Wakana, 2021. "B cell-derived GABA elicits IL-10+ macrophages to limit anti-tumour immunity," Nature, Nature, vol. 599(7885), pages 471-476, November.
    3. Seongbeom Kim & Chi-Yeol Kim & Sook-Young Park & Ki-Tae Kim & Jongbum Jeon & Hyunjung Chung & Gobong Choi & Seomun Kwon & Jaeyoung Choi & Junhyun Jeon & Jong-Seong Jeon & Chang Hyun Khang & Seogchan K, 2020. "Two nuclear effectors of the rice blast fungus modulate host immunity via transcriptional reprogramming," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    4. Saima Shahid & Gunjune Kim & Nathan R. Johnson & Eric Wafula & Feng Wang & Ceyda Coruh & Vivian Bernal-Galeano & Tamia Phifer & Claude W. dePamphilis & James H. Westwood & Michael J. Axtell, 2018. "MicroRNAs from the parasitic plant Cuscuta campestris target host messenger RNAs," Nature, Nature, vol. 553(7686), pages 82-85, January.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Aravind Chandrasekaran & Kristin Graham & Jeanne C. Stachowiak & Padmini Rangamani, 2024. "Kinetic trapping organizes actin filaments within liquid-like protein droplets," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Qianqian Ma & Wahyu Surya & Danxia He & Hanmeng Yang & Xiao Han & Mui Hoon Nai & Chwee Teck Lim & Jaume Torres & Yansong Miao, 2024. "Spa2 remodels ADP-actin via molecular condensation under glucose starvation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    3. Weiliang Zuo & Jasper R. L. Depotter & Sara Christina Stolze & Hirofumi Nakagami & Gunther Doehlemann, 2023. "A transcriptional activator effector of Ustilago maydis regulates hyperplasia in maize during pathogen-induced tumor formation," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Nadia Houerbi & JangKeun Kim & Eliah G. Overbey & Richa Batra & Annalise Schweickart & Laura Patras & Serena Lucotti & Krista A. Ryon & Deena Najjar & Cem Meydan & Namita Damle & Christopher Chin & S., 2024. "Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    5. Baoye He & Huan Wang & Guosheng Liu & Angela Chen & Alejandra Calvo & Qiang Cai & Hailing Jin, 2023. "Fungal small RNAs ride in extracellular vesicles to enter plant cells through clathrin-mediated endocytosis," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    6. Xuetao Shi & Xin Xie & Yuanwen Guo & Junqi Zhang & Ziwen Gong & Kai Zhang & Jie Mei & Xinyao Xia & Haoxue Xia & Na Ning & Yutao Xiao & Qing Yang & Guo-Liang Wang & Wende Liu, 2024. "A fungal core effector exploits the OsPUX8B.2–OsCDC48-6 module to suppress plant immunity," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    7. Anna Kokla & Martina Leso & Xiang Zhang & Jan Simura & Phanu T. Serivichyaswat & Songkui Cui & Karin Ljung & Satoko Yoshida & Charles W. Melnyk, 2022. "Nitrogen represses haustoria formation through abscisic acid in the parasitic plant Phtheirospermum japonicum," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    8. Lei Zhang & Li Jiang & Liang Yu & Qin Li & Xiangjun Tian & Jingquan He & Ling Zeng & Yuqin Yang & Chaoran Wang & Yuhan Wei & Xiaoyue Jiang & Jing Li & Xiaolu Ge & Qisheng Gu & Jikun Li & Di Wu & Antho, 2022. "Inhibition of UBA6 by inosine augments tumour immunogenicity and responses," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-44197-9. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.