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Myeloid cells interact with a subset of thyrocytes to promote their migration and follicle formation through NF-κB

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  • Rui-Meng Yang

    (Shanghai Jiao Tong University School of Medicine)

  • Shi-Yang Song

    (Shanghai Jiao Tong University School of Medicine)

  • Feng-Yao Wu

    (Shanghai Jiao Tong University School of Medicine)

  • Rui-Feng Yang

    (Shanghai Medical College, Fudan University)

  • Yan-Ting Shen

    (Shanghai Jiao Tong University School of Medicine)

  • Ping-Hui Tu

    (Shanghai Jiao Tong University School of Medicine)

  • Zheng Wang

    (Shanghai Jiao Tong University School of Medicine)

  • Jun-Xiu Zhang

    (Maternal and Child Health Institute of Bozhou)

  • Feng Cheng

    (Fujian Medical University)

  • Guan-Qi Gao

    (The Linyi People’s Hospital)

  • Jun Liang

    (The Central Hospital of Xuzhou Affiliated to Xuzhou Medical College)

  • Miao-Miao Guo

    (Shanghai Jiao Tong University School of Medicine)

  • Liu Yang

    (Shanghai Jiao Tong University School of Medicine)

  • Yi Zhou

    (Boston Children’s Hospital and Harvard Stem Cell Institute
    Boston Children’s Hospital and Dana Farber Cancer Institute)

  • Shuang-Xia Zhao

    (Shanghai Jiao Tong University School of Medicine)

  • Ming Zhan

    (Shanghai Jiao Tong University School of Medicine)

  • Huai-Dong Song

    (Shanghai Jiao Tong University School of Medicine)

Abstract

The pathogenesis of thyroid dysgenesis (TD) is not well understood. Here, using a combination of single-cell RNA and spatial transcriptome sequencing, we identify a subgroup of NF-κB-activated thyrocytes located at the center of thyroid tissues in postnatal mice, which maintained a partially mesenchymal phenotype. These cells actively protruded out of the thyroid primordium and generated new follicles in zebrafish embryos through continuous tracing. Suppressing NF-κB signaling affected thyrocyte migration and follicle formation, leading to a TD-like phenotype in both mice and zebrafish. Interestingly, during thyroid folliculogenesis, myeloid cells played a crucial role in promoting thyrocyte migration by maintaining close contact and secreting TNF-α. We found that cebpa mutant zebrafish, in which all myeloid cells were depleted, exhibited thyrocyte migration defects. Taken together, our results suggest that myeloid-derived TNF-α-induced NF-κB activation plays a critical role in promoting the migration of vertebrate thyrocytes for follicle generation.

Suggested Citation

  • Rui-Meng Yang & Shi-Yang Song & Feng-Yao Wu & Rui-Feng Yang & Yan-Ting Shen & Ping-Hui Tu & Zheng Wang & Jun-Xiu Zhang & Feng Cheng & Guan-Qi Gao & Jun Liang & Miao-Miao Guo & Liu Yang & Yi Zhou & Shu, 2023. "Myeloid cells interact with a subset of thyrocytes to promote their migration and follicle formation through NF-κB," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43895-8
    DOI: 10.1038/s41467-023-43895-8
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    Cited by:

    1. Ya Fang & Jia-Ping Wan & Zheng Wang & Shi-Yang Song & Cao-Xu Zhang & Liu Yang & Qian-Yue Zhang & Chen-Yan Yan & Feng-Yao Wu & Sang-Yu Lu & Feng Sun & Bing Han & Shuang-Xia Zhao & Mei Dong & Huai-Dong , 2024. "Deficiency of the HGF/Met pathway leads to thyroid dysgenesis by impeding late thyroid expansion," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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