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Single-cell reconstruction of the early maternal–fetal interface in humans

Author

Listed:
  • Roser Vento-Tormo

    (Wellcome Sanger Institute
    University of Cambridge)

  • Mirjana Efremova

    (Wellcome Sanger Institute)

  • Rachel A. Botting

    (Newcastle University)

  • Margherita Y. Turco

    (University of Cambridge
    University of Cambridge
    University of Cambridge)

  • Miquel Vento-Tormo

    (YDEVS software development)

  • Kerstin B. Meyer

    (Wellcome Sanger Institute)

  • Jong-Eun Park

    (Wellcome Sanger Institute)

  • Emily Stephenson

    (Newcastle University)

  • Krzysztof Polański

    (Wellcome Sanger Institute)

  • Angela Goncalves

    (Wellcome Sanger Institute
    German Cancer Research Center (DKFZ))

  • Lucy Gardner

    (University of Cambridge
    University of Cambridge)

  • Staffan Holmqvist

    (Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge)

  • Johan Henriksson

    (Wellcome Sanger Institute)

  • Angela Zou

    (Wellcome Sanger Institute)

  • Andrew M. Sharkey

    (University of Cambridge
    University of Cambridge)

  • Ben Millar

    (Newcastle University)

  • Barbara Innes

    (Newcastle University)

  • Laura Wood

    (Wellcome Sanger Institute)

  • Anna Wilbrey-Clark

    (Wellcome Sanger Institute)

  • Rebecca P. Payne

    (Newcastle University)

  • Martin A. Ivarsson

    (University of Cambridge)

  • Steve Lisgo

    (Institute of Genetic Medicine, Newcastle University)

  • Andrew Filby

    (Newcastle University)

  • David H. Rowitch

    (Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge)

  • Judith N. Bulmer

    (Newcastle University)

  • Gavin J. Wright

    (Wellcome Sanger Institute)

  • Michael J. T. Stubbington

    (Wellcome Sanger Institute)

  • Muzlifah Haniffa

    (Wellcome Sanger Institute
    Newcastle University
    Newcastle Hospitals NHS Foundation Trust)

  • Ashley Moffett

    (University of Cambridge
    University of Cambridge)

  • Sarah A. Teichmann

    (Wellcome Sanger Institute
    University of Cambridge
    European Bioinformatics Institute (EMBL-EBI))

Abstract

During early human pregnancy the uterine mucosa transforms into the decidua, into which the fetal placenta implants and where placental trophoblast cells intermingle and communicate with maternal cells. Trophoblast–decidual interactions underlie common diseases of pregnancy, including pre-eclampsia and stillbirth. Here we profile the transcriptomes of about 70,000 single cells from first-trimester placentas with matched maternal blood and decidual cells. The cellular composition of human decidua reveals subsets of perivascular and stromal cells that are located in distinct decidual layers. There are three major subsets of decidual natural killer cells that have distinctive immunomodulatory and chemokine profiles. We develop a repository of ligand–receptor complexes and a statistical tool to predict the cell-type specificity of cell–cell communication via these molecular interactions. Our data identify many regulatory interactions that prevent harmful innate or adaptive immune responses in this environment. Our single-cell atlas of the maternal–fetal interface reveals the cellular organization of the decidua and placenta, and the interactions that are critical for placentation and reproductive success.

Suggested Citation

  • Roser Vento-Tormo & Mirjana Efremova & Rachel A. Botting & Margherita Y. Turco & Miquel Vento-Tormo & Kerstin B. Meyer & Jong-Eun Park & Emily Stephenson & Krzysztof Polański & Angela Goncalves & Lucy, 2018. "Single-cell reconstruction of the early maternal–fetal interface in humans," Nature, Nature, vol. 563(7731), pages 347-353, November.
    • Handle: RePEc:nat:nature:v:563:y:2018:i:7731:d:10.1038_s41586-018-0698-6
    DOI: 10.1038/s41586-018-0698-6
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