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Potential solutions for manufacture of CAR T cells in cancer immunotherapy

Author

Listed:
  • Ulrich Blache

    (Fraunhofer Institute for Cell Therapy and Immunology (IZI)
    Fraunhofer Cluster of Excellence for Immune-Mediated Disease)

  • Georg Popp

    (Fraunhofer Institute for Cell Therapy and Immunology (IZI))

  • Anna Dünkel

    (Fraunhofer Institute for Cell Therapy and Immunology (IZI))

  • Ulrike Koehl

    (Fraunhofer Institute for Cell Therapy and Immunology (IZI)
    Fraunhofer Cluster of Excellence for Immune-Mediated Disease
    University of Leipzig)

  • Stephan Fricke

    (Fraunhofer Institute for Cell Therapy and Immunology (IZI)
    Fraunhofer Cluster of Excellence for Immune-Mediated Disease)

Abstract

CAR T cell therapy is an effective cancer treatment, but biological and manufacturing hurdles hamper its broad breakthrough. Although the first step towards automated manufacture of CAR cells has been taken, new technologies are needed to enable the treatment of large patient groups.

Suggested Citation

  • Ulrich Blache & Georg Popp & Anna Dünkel & Ulrike Koehl & Stephan Fricke, 2022. "Potential solutions for manufacture of CAR T cells in cancer immunotherapy," Nature Communications, Nature, vol. 13(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32866-0
    DOI: 10.1038/s41467-022-32866-0
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    References listed on IDEAS

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    1. J. Joseph Melenhorst & Gregory M. Chen & Meng Wang & David L. Porter & Changya Chen & McKensie A. Collins & Peng Gao & Shovik Bandyopadhyay & Hongxing Sun & Ziran Zhao & Stefan Lundh & Iulian Pruteanu, 2022. "Decade-long leukaemia remissions with persistence of CD4+ CAR T cells," Nature, Nature, vol. 602(7897), pages 503-509, February.
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