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A distinct Acyl-CoA binding protein (ACBP6) shapes tissue plasticity during nutrient adaptation in Drosophila

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  • Xiaotong Li

    (Texas A&M University, School of Medicine)

  • Jason Karpac

    (Texas A&M University, School of Medicine)

Abstract

Nutrient availability is a major selective force in the evolution of metazoa, and thus plasticity in tissue function and morphology is shaped by adaptive responses to nutrient changes. Utilizing Drosophila, we reveal that distinct calibration of acyl-CoA metabolism, mediated by Acbp6 (Acyl-CoA binding-protein 6), is critical for nutrient-dependent tissue plasticity. Drosophila Acbp6, which arose by evolutionary duplication and binds acyl-CoA to tune acetyl-CoA metabolism, is required for intestinal resizing after nutrient deprivation through activating intestinal stem cell proliferation from quiescence. Disruption of acyl-CoA metabolism by Acbp6 attenuation drives aberrant ‘switching’ of metabolic networks in intestinal enterocytes during nutrient adaptation, impairing acetyl-CoA metabolism and acetylation amid intestinal resizing. We also identified STAT92e, whose function is influenced by acetyl-CoA levels, as a key regulator of acyl-CoA and nutrient-dependent changes in stem cell activation. These findings define a regulatory mechanism, shaped by acyl-CoA metabolism, that adjusts proliferative homeostasis to coordinately regulate tissue plasticity during nutrient adaptation.

Suggested Citation

  • Xiaotong Li & Jason Karpac, 2023. "A distinct Acyl-CoA binding protein (ACBP6) shapes tissue plasticity during nutrient adaptation in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43362-4
    DOI: 10.1038/s41467-023-43362-4
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    References listed on IDEAS

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    1. Sean B. Carroll, 2001. "Chance and necessity: the evolution of morphological complexity and diversity," Nature, Nature, vol. 409(6823), pages 1102-1109, February.
    2. Jackson Liang & Shruthi Balachandra & Sang Ngo & Lucy Erin O’Brien, 2017. "Feedback regulation of steady-state epithelial turnover and organ size," Nature, Nature, vol. 548(7669), pages 588-591, August.
    3. Daniel Wilinski & Jasmine Winzeler & William Duren & Jenna L. Persons & Kristina J. Holme & Johan Mosquera & Morteza Khabiri & Jason M. Kinchen & Peter L. Freddolino & Alla Karnovsky & Monica Dus, 2019. "Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    4. Philipp Mews & Greg Donahue & Adam M. Drake & Vincent Luczak & Ted Abel & Shelley L. Berger, 2017. "Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory," Nature, Nature, vol. 546(7658), pages 381-386, June.
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