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Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster

Author

Listed:
  • Daniel Wilinski

    (The University of Michigan, College of Literature, Science, and the Arts)

  • Jasmine Winzeler

    (The University of Michigan, College of Literature, Science, and the Arts)

  • William Duren

    (The University of Michigan Medical School)

  • Jenna L. Persons

    (The University of Michigan, College of Literature, Science, and the Arts)

  • Kristina J. Holme

    (The University of Michigan Medical School)

  • Johan Mosquera

    (The University of Michigan Medical School)

  • Morteza Khabiri

    (The University of Michigan Medical School)

  • Jason M. Kinchen

    (Metabolon, Inc)

  • Peter L. Freddolino

    (The University of Michigan Medical School
    The University of Michigan Medical School)

  • Alla Karnovsky

    (The University of Michigan Medical School)

  • Monica Dus

    (The University of Michigan, College of Literature, Science, and the Arts)

Abstract

Metabolites are active controllers of cellular physiology, but their role in complex behaviors is less clear. Here we report metabolic changes that occur during the transition between hunger and satiety in Drosophila melanogaster. To analyze these data in the context of fruit fly metabolic networks, we developed Flyscape, an open-access tool. We show that in response to eating, metabolic profiles change in quick, but distinct ways in the heads and bodies. Consumption of a high sugar diet dulls the metabolic and behavioral differences between the fasted and fed state, and reshapes the way nutrients are utilized upon eating. Specifically, we found that high dietary sugar increases TCA cycle activity, alters neurochemicals, and depletes 1-carbon metabolism and brain health metabolites N-acetyl-aspartate and kynurenine. Together, our work identifies the metabolic transitions that occur during hunger and satiation, and provides a platform to study the role of metabolites and diet in complex behavior.

Suggested Citation

  • Daniel Wilinski & Jasmine Winzeler & William Duren & Jenna L. Persons & Kristina J. Holme & Johan Mosquera & Morteza Khabiri & Jason M. Kinchen & Peter L. Freddolino & Alla Karnovsky & Monica Dus, 2019. "Rapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-11933-z
    DOI: 10.1038/s41467-019-11933-z
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    Cited by:

    1. Xiaotong Li & Jason Karpac, 2023. "A distinct Acyl-CoA binding protein (ACBP6) shapes tissue plasticity during nutrient adaptation in Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Ellen McMullen & Helen Hertenstein & Katrin Strassburger & Leon Deharde & Marko Brankatschk & Stefanie Schirmeier, 2023. "Glycolytically impaired Drosophila glial cells fuel neural metabolism via β-oxidation," Nature Communications, Nature, vol. 14(1), pages 1-9, December.

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