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An oocyte meiotic midbody cap is required for developmental competence in mice

Author

Listed:
  • Gyu Ik Jung

    (The State University of New Jersey
    Human Genetics Institute of New Jersey)

  • Daniela Londoño-Vásquez

    (University of Missouri)

  • Sungjin Park

    (University of Wisconsin-Madison)

  • Ahna R. Skop

    (University of Wisconsin-Madison)

  • Ahmed Z. Balboula

    (University of Missouri)

  • Karen Schindler

    (The State University of New Jersey
    Human Genetics Institute of New Jersey)

Abstract

Embryo development depends upon maternally derived materials. Mammalian oocytes undergo extreme asymmetric cytokinesis events, producing one large egg and two small polar bodies. During cytokinesis in somatic cells, the midbody and subsequent assembly of the midbody remnant, a signaling organelle containing RNAs, transcription factors and translation machinery, is thought to influence cellular function or fate. The role of the midbody and midbody remnant in gametes, in particular, oocytes, remains unclear. Here, we examined the formation and function of meiotic midbodies (mMB) and mMB remnants using mouse oocytes and demonstrate that mMBs have a specialized cap structure that is orientated toward polar bodies. We show that that mMBs are translationally active, and that mMB caps are required to retain nascent proteins in eggs. We propose that this specialized mMB cap maintains genetic factors in eggs allowing for full developmental competency.

Suggested Citation

  • Gyu Ik Jung & Daniela Londoño-Vásquez & Sungjin Park & Ahna R. Skop & Ahmed Z. Balboula & Karen Schindler, 2023. "An oocyte meiotic midbody cap is required for developmental competence in mice," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43288-x
    DOI: 10.1038/s41467-023-43288-x
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    References listed on IDEAS

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    1. Luisa Capalbo & Zuni I. Bassi & Marco Geymonat & Sofia Todesca & Liviu Copoiu & Anton J. Enright & Giuliano Callaini & Maria Giovanna Riparbelli & Lu Yu & Jyoti S. Choudhary & Enrico Ferrero & Sally W, 2019. "The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis," Nature Communications, Nature, vol. 10(1), pages 1-17, December.
    2. Azelle Hawdon & Niall D. Geoghegan & Monika Mohenska & Anja Elsenhans & Charles Ferguson & Jose M. Polo & Robert G. Parton & Jennifer Zenker, 2023. "Apicobasal RNA asymmetries regulate cell fate in the early mouse embryo," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Thomas Wollert & Christian Wunder & Jennifer Lippincott-Schwartz & James H. Hurley, 2009. "Membrane scission by the ESCRT-III complex," Nature, Nature, vol. 458(7235), pages 172-177, March.
    4. Cai-Rong Yang & Gabriel Rajkovic & Enrico Maria Daldello & Xuan G. Luong & Jing Chen & Marco Conti, 2020. "The RNA-binding protein DAZL functions as repressor and activator of mRNA translation during oocyte maturation," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
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