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Diatomic iron nanozyme with lipoxidase-like activity for efficient inactivation of enveloped virus

Author

Listed:
  • Beibei Li

    (Tsinghua University
    Tsinghua University
    Henan University)

  • Ruonan Ma

    (Chinese Academy of Sciences)

  • Lei Chen

    (Chinese Academy of Sciences
    Yangzhou University)

  • Caiyu Zhou

    (Chinese Academy of Sciences)

  • Yu-Xiao Zhang

    (Tsinghua University)

  • Xiaonan Wang

    (Chinese Academy of Sciences)

  • Helai Huang

    (Tsinghua University)

  • Qikun Hu

    (Tsinghua University)

  • Xiaobo Zheng

    (Tsinghua University)

  • Jiarui Yang

    (Tsinghua University)

  • Mengjuan Shao

    (Yangzhou University)

  • Pengfei Hao

    (Chinese Academy of Agricultural Sciences)

  • Yanfen Wu

    (Tsinghua University)

  • Yizhen Che

    (Tsinghua University)

  • Chang Li

    (Chinese Academy of Agricultural Sciences)

  • Tao Qin

    (Yangzhou University)

  • Lizeng Gao

    (Chinese Academy of Sciences)

  • Zhiqiang Niu

    (Tsinghua University)

  • Yadong Li

    (Tsinghua University)

Abstract

Enveloped viruses encased within a lipid bilayer membrane are highly contagious and can cause many infectious diseases like influenza and COVID-19, thus calling for effective prevention and inactivation strategies. Here, we develop a diatomic iron nanozyme with lipoxidase-like (LOX-like) activity for the inactivation of enveloped virus. The diatomic iron sites can destruct the viral envelope via lipid peroxidation, thus displaying non-specific virucidal property. In contrast, natural LOX exhibits low antiviral performance, manifesting the advantage of nanozyme over the natural enzyme. Theoretical studies suggest that the Fe-O-Fe motif can match well the energy levels of Fe2 minority β-spin d orbitals and pentadiene moiety π* orbitals, and thus significantly lower the activation barrier of cis,cis-1,4-pentadiene moiety in the vesicle membrane. We showcase that the diatomic iron nanozyme can be incorporated into air purifier to disinfect airborne flu virus. The present strategy promises a future application in comprehensive biosecurity control.

Suggested Citation

  • Beibei Li & Ruonan Ma & Lei Chen & Caiyu Zhou & Yu-Xiao Zhang & Xiaonan Wang & Helai Huang & Qikun Hu & Xiaobo Zheng & Jiarui Yang & Mengjuan Shao & Pengfei Hao & Yanfen Wu & Yizhen Che & Chang Li & T, 2023. "Diatomic iron nanozyme with lipoxidase-like activity for efficient inactivation of enveloped virus," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43176-4
    DOI: 10.1038/s41467-023-43176-4
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    References listed on IDEAS

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    1. Samir Bhatt & Peter W. Gething & Oliver J. Brady & Jane P. Messina & Andrew W. Farlow & Catherine L. Moyes & John M. Drake & John S. Brownstein & Anne G. Hoen & Osman Sankoh & Monica F. Myers & Dylan , 2013. "The global distribution and burden of dengue," Nature, Nature, vol. 496(7446), pages 504-507, April.
    2. Travis Marshall-Roth & Nicole J. Libretto & Alexandra T. Wrobel & Kevin J. Anderton & Michael L. Pegis & Nathan D. Ricke & Troy Van Voorhis & Jeffrey T. Miller & Yogesh Surendranath, 2020. "A pyridinic Fe-N4 macrocycle models the active sites in Fe/N-doped carbon electrocatalysts," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
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