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Combinatorial quantification of distinct neural projections from retrograde tracing

Author

Listed:
  • Siva Venkadesh

    (George Mason University
    George Mason University)

  • Anthony Santarelli

    (University of California Los Angeles)

  • Tyler Boesen

    (University of California Los Angeles)

  • Hong-Wei Dong

    (University of California Los Angeles)

  • Giorgio A. Ascoli

    (George Mason University
    George Mason University)

Abstract

Comprehensive quantification of neuronal architectures underlying anatomical brain connectivity remains challenging. We introduce a method to identify distinct axonal projection patterns from a source to a set of target regions and the count of neurons with each pattern. A source region projecting to n targets could have 2n-1 theoretically possible projection types, although only a subset of these types typically exists. By injecting uniquely labeled retrograde tracers in k target regions (k

Suggested Citation

  • Siva Venkadesh & Anthony Santarelli & Tyler Boesen & Hong-Wei Dong & Giorgio A. Ascoli, 2023. "Combinatorial quantification of distinct neural projections from retrograde tracing," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43124-2
    DOI: 10.1038/s41467-023-43124-2
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    1. Nicholas N. Foster & Joshua Barry & Laura Korobkova & Luis Garcia & Lei Gao & Marlene Becerra & Yasmine Sherafat & Bo Peng & Xiangning Li & Jun-Hyeok Choi & Lin Gou & Brian Zingg & Sana Azam & Darrick, 2021. "The mouse cortico–basal ganglia–thalamic network," Nature, Nature, vol. 598(7879), pages 188-194, October.
    2. Julie A. Harris & Stefan Mihalas & Karla E. Hirokawa & Jennifer D. Whitesell & Hannah Choi & Amy Bernard & Phillip Bohn & Shiella Caldejon & Linzy Casal & Andrew Cho & Aaron Feiner & David Feng & Nath, 2019. "Hierarchical organization of cortical and thalamic connectivity," Nature, Nature, vol. 575(7781), pages 195-202, November.
    3. Bryan M. Hooks & Andrew E. Papale & Ronald F. Paletzki & Muhammad W. Feroze & Brian S. Eastwood & Jonathan J. Couey & Johan Winnubst & Jayaram Chandrashekar & Charles R. Gerfen, 2018. "Topographic precision in sensory and motor corticostriatal projections varies across cell type and cortical area," Nature Communications, Nature, vol. 9(1), pages 1-16, December.
    4. Rita Abban & S.W.F. (Onno) Omta & John B.K. Aheto & V.E. Scholten, 2013. "Connecting the dots," African Journal of Economic and Management Studies, Emerald Group Publishing Limited, vol. 4(1), pages 74-94, April.
    5. Houri Hintiryan & Ian Bowman & David L. Johnson & Laura Korobkova & Muye Zhu & Neda Khanjani & Lin Gou & Lei Gao & Seita Yamashita & Michael S. Bienkowski & Luis Garcia & Nicholas N. Foster & Nora L. , 2021. "Connectivity characterization of the mouse basolateral amygdalar complex," Nature Communications, Nature, vol. 12(1), pages 1-25, December.
    6. Rita Abban & S.W.F. (Onno) Omta & John B.K. Aheto & V.E. Scholten, 2013. "Connecting the dots," African Journal of Economic and Management Studies, Emerald Group Publishing Limited, vol. 4(1), pages 74-94, April.
    7. Bryan M. Hooks & Andrew E. Papale & Ronald F. Paletzki & Muhammad W. Feroze & Brian S. Eastwood & Jonathan J. Couey & Johan Winnubst & Jayaram Chandrashekar & Charles R. Gerfen, 2018. "Author Correction: Topographic precision in sensory and motor corticostriatal projections varies across cell type and cortical area," Nature Communications, Nature, vol. 9(1), pages 1-1, December.
    8. Seung Wook Oh & Julie A. Harris & Lydia Ng & Brent Winslow & Nicholas Cain & Stefan Mihalas & Quanxin Wang & Chris Lau & Leonard Kuan & Alex M. Henry & Marty T. Mortrud & Benjamin Ouellette & Thuc Ngh, 2014. "A mesoscale connectome of the mouse brain," Nature, Nature, vol. 508(7495), pages 207-214, April.
    9. Wenjing Yin & Derrick Brittain & Jay Borseth & Marie E. Scott & Derric Williams & Jedediah Perkins & Christopher S. Own & Matthew Murfitt & Russel M. Torres & Daniel Kapner & Gayathri Mahalingam & Ada, 2020. "A petascale automated imaging pipeline for mapping neuronal circuits with high-throughput transmission electron microscopy," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    10. Baoyindureng Wu & Xinhui An & Guojie Liu & Guiying Yan & Xiaoping Liu, 2013. "Minimum degree, edge-connectivity and radius," Journal of Combinatorial Optimization, Springer, vol. 26(3), pages 585-591, October.
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