Author
Listed:
- Nicholas N. Foster
(David Geffen School of Medicine at UCLA
University of Southern California)
- Joshua Barry
(David Geffen School of Medicine at UCLA)
- Laura Korobkova
(University of Southern California)
- Luis Garcia
(David Geffen School of Medicine at UCLA
University of Southern California)
- Lei Gao
(David Geffen School of Medicine at UCLA
University of Southern California)
- Marlene Becerra
(University of Southern California)
- Yasmine Sherafat
(University of Southern California)
- Bo Peng
(University of Southern California)
- Xiangning Li
(Huazhong University of Science and Technology
JITRI Institute for Brainsmatics)
- Jun-Hyeok Choi
(University of California, San Diego)
- Lin Gou
(David Geffen School of Medicine at UCLA
University of Southern California)
- Brian Zingg
(David Geffen School of Medicine at UCLA
University of Southern California)
- Sana Azam
(University of Southern California)
- Darrick Lo
(David Geffen School of Medicine at UCLA
University of Southern California)
- Neda Khanjani
(University of Southern California)
- Bin Zhang
(David Geffen School of Medicine at UCLA
University of Southern California)
- Jim Stanis
(University of Southern California)
- Ian Bowman
(David Geffen School of Medicine at UCLA
University of Southern California)
- Kaelan Cotter
(University of Southern California)
- Chunru Cao
(David Geffen School of Medicine at UCLA
University of Southern California)
- Seita Yamashita
(David Geffen School of Medicine at UCLA
University of Southern California)
- Amanda Tugangui
(David Geffen School of Medicine at UCLA
University of Southern California)
- Anan Li
(Huazhong University of Science and Technology
JITRI Institute for Brainsmatics
Chinese Academy of Science)
- Tao Jiang
(JITRI Institute for Brainsmatics)
- Xueyan Jia
(JITRI Institute for Brainsmatics)
- Zhao Feng
(JITRI Institute for Brainsmatics)
- Sarvia Aquino
(University of Southern California)
- Hyun-Seung Mun
(David Geffen School of Medicine at UCLA
University of Southern California)
- Muye Zhu
(David Geffen School of Medicine at UCLA
University of Southern California)
- Anthony Santarelli
(University of Southern California)
- Nora L. Benavidez
(David Geffen School of Medicine at UCLA
University of Southern California)
- Monica Song
(David Geffen School of Medicine at UCLA
University of Southern California)
- Gordon Dan
(University of Southern California)
- Marina Fayzullina
(David Geffen School of Medicine at UCLA
University of Southern California)
- Sarah Ustrell
(University of Southern California)
- Tyler Boesen
(David Geffen School of Medicine at UCLA
University of Southern California)
- David L. Johnson
(University of Southern California)
- Hanpeng Xu
(David Geffen School of Medicine at UCLA
University of Southern California)
- Michael S. Bienkowski
(University of Southern California)
- X. William Yang
(David Geffen School of Medicine at UCLA
Jane and Terry Semel Institute for Neuroscience)
- Hui Gong
(Huazhong University of Science and Technology
JITRI Institute for Brainsmatics
Chinese Academy of Science)
- Michael S. Levine
(David Geffen School of Medicine at UCLA)
- Ian Wickersham
(Massachusetts Institute of Technology)
- Qingming Luo
(Huazhong University of Science and Technology
JITRI Institute for Brainsmatics
Hainan University)
- Joel D. Hahn
(University of Southern California)
- Byung Kook Lim
(University of California, San Diego)
- Li I. Zhang
(University of Southern California)
- Carlos Cepeda
(David Geffen School of Medicine at UCLA)
- Houri Hintiryan
(David Geffen School of Medicine at UCLA
University of Southern California)
- Hong-Wei Dong
(David Geffen School of Medicine at UCLA
University of Southern California)
Abstract
The cortico–basal ganglia–thalamo–cortical loop is one of the fundamental network motifs in the brain. Revealing its structural and functional organization is critical to understanding cognition, sensorimotor behaviour, and the natural history of many neurological and neuropsychiatric disorders. Classically, this network is conceptualized to contain three information channels: motor, limbic and associative1–4. Yet this three-channel view cannot explain the myriad functions of the basal ganglia. We previously subdivided the dorsal striatum into 29 functional domains on the basis of the topography of inputs from the entire cortex5. Here we map the multi-synaptic output pathways of these striatal domains through the globus pallidus external part (GPe), substantia nigra reticular part (SNr), thalamic nuclei and cortex. Accordingly, we identify 14 SNr and 36 GPe domains and a direct cortico-SNr projection. The striatonigral direct pathway displays a greater convergence of striatal inputs than the more parallel striatopallidal indirect pathway, although direct and indirect pathways originating from the same striatal domain ultimately converge onto the same postsynaptic SNr neurons. Following the SNr outputs, we delineate six domains in the parafascicular and ventromedial thalamic nuclei. Subsequently, we identify six parallel cortico–basal ganglia–thalamic subnetworks that sequentially transduce specific subsets of cortical information through every elemental node of the cortico–basal ganglia–thalamic loop. Thalamic domains relay this output back to the originating corticostriatal neurons of each subnetwork in a bona fide closed loop.
Suggested Citation
Nicholas N. Foster & Joshua Barry & Laura Korobkova & Luis Garcia & Lei Gao & Marlene Becerra & Yasmine Sherafat & Bo Peng & Xiangning Li & Jun-Hyeok Choi & Lin Gou & Brian Zingg & Sana Azam & Darrick, 2021.
"The mouse cortico–basal ganglia–thalamic network,"
Nature, Nature, vol. 598(7879), pages 188-194, October.
Handle:
RePEc:nat:nature:v:598:y:2021:i:7879:d:10.1038_s41586-021-03993-3
DOI: 10.1038/s41586-021-03993-3
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Cited by:
- Fae N. Kronman & Josephine K. Liwang & Rebecca Betty & Daniel J. Vanselow & Yuan-Ting Wu & Nicholas J. Tustison & Ashwin Bhandiwad & Steffy B. Manjila & Jennifer A. Minteer & Donghui Shin & Choong Heo, 2024.
"Developmental mouse brain common coordinate framework,"
Nature Communications, Nature, vol. 15(1), pages 1-17, December.
- Roberto de la Torre-Martinez & Maya Ketzef & Gilad Silberberg, 2023.
"Ongoing movement controls sensory integration in the dorsolateral striatum,"
Nature Communications, Nature, vol. 14(1), pages 1-16, December.
- Tadaaki Nishioka & Suthinee Attachaipanich & Kosuke Hamaguchi & Michael Lazarus & Alban Kerchove d’Exaerde & Tom Macpherson & Takatoshi Hikida, 2023.
"Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice,"
Nature Communications, Nature, vol. 14(1), pages 1-15, December.
- Siva Venkadesh & Anthony Santarelli & Tyler Boesen & Hong-Wei Dong & Giorgio A. Ascoli, 2023.
"Combinatorial quantification of distinct neural projections from retrograde tracing,"
Nature Communications, Nature, vol. 14(1), pages 1-10, December.
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