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ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries

Author

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  • Josephine Bowles

    (Institute for Molecular Bioscience, The University of Queensland)

  • Chun-Wei Feng

    (Institute for Molecular Bioscience, The University of Queensland)

  • Kim Miles

    (Institute for Molecular Bioscience, The University of Queensland)

  • Jessica Ineson

    (Institute for Molecular Bioscience, The University of Queensland)

  • Cassy Spiller

    (Institute for Molecular Bioscience, The University of Queensland)

  • Peter Koopman

    (Institute for Molecular Bioscience, The University of Queensland)

Abstract

Substantial evidence exists that during fetal ovarian development in mammals, retinoic acid (RA) induces germ cells to express the pre-meiotic marker Stra8 and enter meiosis, and that these effects are prevented in the fetal testis by the RA-degrading P450 enzyme CYP26B1. Nonetheless, the role of RA has been disputed principally because germ cells in embryos lacking two major RA-synthesizing enzymes, ALDH1A2 and ALDH1A3, remain able to enter meiosis. Here we show that a third RA-synthesizing enzyme, ALDH1A1, is expressed in fetal ovaries, providing a likely source of RA in the absence of ALDH1A2 and ALDH1A3. In ovaries lacking ALDH1A1, the onset of germ cell meiosis is delayed. Our data resolve the conundrum posed by conflicting published data sets and reconfirm the model that meiosis is triggered by endogenous RA in the developing ovary.

Suggested Citation

  • Josephine Bowles & Chun-Wei Feng & Kim Miles & Jessica Ineson & Cassy Spiller & Peter Koopman, 2016. "ALDH1A1 provides a source of meiosis-inducing retinoic acid in mouse fetal ovaries," Nature Communications, Nature, vol. 7(1), pages 1-8, April.
    • Handle: RePEc:nat:natcom:v:7:y:2016:i:1:d:10.1038_ncomms10845
    DOI: 10.1038/ncomms10845
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    Cited by:

    1. Ryuki Shimada & Yuzuru Kato & Naoki Takeda & Sayoko Fujimura & Kei-ichiro Yasunaga & Shingo Usuki & Hitoshi Niwa & Kimi Araki & Kei-ichiro Ishiguro, 2023. "STRA8–RB interaction is required for timely entry of meiosis in mouse female germ cells," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

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