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NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers

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  • Kazuhiro Murakami

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,
    Laboratory for Pluripotent Cell Studies, Center for Developmental Biology, RIKEN)

  • Ufuk Günesdogan

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • Jan J. Zylicz

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • Walfred W. C. Tang

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • Roopsha Sengupta

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • Toshihiro Kobayashi

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • Shinseog Kim

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • Richard Butler

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge)

  • Sabine Dietmann

    (Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • M. Azim Surani

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

Abstract

In mouse embryonic stem cells converted to an epiblast fate in vitro—a state in which the cells can also gain germ cell fate if exposed to the signalling molecule BMP4—the sole expression of the transcription factor NANOG is shown to be sufficient to induce germ cell fate, in the absence of BMP4.

Suggested Citation

  • Kazuhiro Murakami & Ufuk Günesdogan & Jan J. Zylicz & Walfred W. C. Tang & Roopsha Sengupta & Toshihiro Kobayashi & Shinseog Kim & Richard Butler & Sabine Dietmann & M. Azim Surani, 2016. "NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers," Nature, Nature, vol. 529(7586), pages 403-407, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7586:d:10.1038_nature16480
    DOI: 10.1038/nature16480
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    Cited by:

    1. Sivakamasundari Vijayakumar & Roberta Sala & Gugene Kang & Angela Chen & Michelle Ann Pablo & Abidemi Ismail Adebayo & Andrea Cipriano & Jonas L. Fowler & Danielle L. Gomes & Lay Teng Ang & Kyle M. Lo, 2023. "Monolayer platform to generate and purify primordial germ-like cells in vitro provides insights into human germline specification," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Xiaosi Wang & Junwen Zhu & Houpeng Wang & Wenqi Deng & Shengbo Jiao & Yaqing Wang & Mudan He & Fenghua Zhang & Tao Liu & Yongkang Hao & Ding Ye & Yonghua Sun, 2023. "Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Ryuki Shimada & Yuzuru Kato & Naoki Takeda & Sayoko Fujimura & Kei-ichiro Yasunaga & Shingo Usuki & Hitoshi Niwa & Kimi Araki & Kei-ichiro Ishiguro, 2023. "STRA8–RB interaction is required for timely entry of meiosis in mouse female germ cells," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    4. Shengyong Yu & Chunhua Zhou & Jiangping He & Zhaokai Yao & Xingnan Huang & Bowen Rong & Hong Zhu & Shijie Wang & Shuyan Chen & Xialian Wang & Baomei Cai & Guoqing Zhao & Yuhan Chen & Lizhan Xiao & He , 2022. "BMP4 drives primed to naïve transition through PGC-like state," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Xinwei Liu & Yingying Ye & Liling Zhu & Xiaoyun Xiao & Boxuan Zhou & Yuanting Gu & Hang Si & Huixin Liang & Mingzhu Liu & Jiaqian Li & Qiongchao Jiang & Jiang Li & Shubin Yu & Ruiying Ma & Shicheng Su, 2023. "Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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