IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v529y2016i7586d10.1038_nature16480.html
   My bibliography  Save this article

NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers

Author

Listed:
  • Kazuhiro Murakami

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,
    Laboratory for Pluripotent Cell Studies, Center for Developmental Biology, RIKEN)

  • Ufuk Günesdogan

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • Jan J. Zylicz

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • Walfred W. C. Tang

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • Roopsha Sengupta

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • Toshihiro Kobayashi

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • Shinseog Kim

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • Richard Butler

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge)

  • Sabine Dietmann

    (Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

  • M. Azim Surani

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
    Development and Neuroscience, University of Cambridge
    Wellcome Trust Medical Research Council Stem Cell Institute, University of Cambridge,)

Abstract

In mouse embryonic stem cells converted to an epiblast fate in vitro—a state in which the cells can also gain germ cell fate if exposed to the signalling molecule BMP4—the sole expression of the transcription factor NANOG is shown to be sufficient to induce germ cell fate, in the absence of BMP4.

Suggested Citation

  • Kazuhiro Murakami & Ufuk Günesdogan & Jan J. Zylicz & Walfred W. C. Tang & Roopsha Sengupta & Toshihiro Kobayashi & Shinseog Kim & Richard Butler & Sabine Dietmann & M. Azim Surani, 2016. "NANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers," Nature, Nature, vol. 529(7586), pages 403-407, January.
    • Handle: RePEc:nat:nature:v:529:y:2016:i:7586:d:10.1038_nature16480
    DOI: 10.1038/nature16480
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature16480
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature16480?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sivakamasundari Vijayakumar & Roberta Sala & Gugene Kang & Angela Chen & Michelle Ann Pablo & Abidemi Ismail Adebayo & Andrea Cipriano & Jonas L. Fowler & Danielle L. Gomes & Lay Teng Ang & Kyle M. Lo, 2023. "Monolayer platform to generate and purify primordial germ-like cells in vitro provides insights into human germline specification," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Xiaosi Wang & Junwen Zhu & Houpeng Wang & Wenqi Deng & Shengbo Jiao & Yaqing Wang & Mudan He & Fenghua Zhang & Tao Liu & Yongkang Hao & Ding Ye & Yonghua Sun, 2023. "Induced formation of primordial germ cells from zebrafish blastomeres by germplasm factors," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    3. Shengyong Yu & Chunhua Zhou & Jiangping He & Zhaokai Yao & Xingnan Huang & Bowen Rong & Hong Zhu & Shijie Wang & Shuyan Chen & Xialian Wang & Baomei Cai & Guoqing Zhao & Yuhan Chen & Lizhan Xiao & He , 2022. "BMP4 drives primed to naïve transition through PGC-like state," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Xinwei Liu & Yingying Ye & Liling Zhu & Xiaoyun Xiao & Boxuan Zhou & Yuanting Gu & Hang Si & Huixin Liang & Mingzhu Liu & Jiaqian Li & Qiongchao Jiang & Jiang Li & Shubin Yu & Ruiying Ma & Shicheng Su, 2023. "Niche stiffness sustains cancer stemness via TAZ and NANOG phase separation," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    5. Ryuki Shimada & Yuzuru Kato & Naoki Takeda & Sayoko Fujimura & Kei-ichiro Yasunaga & Shingo Usuki & Hitoshi Niwa & Kimi Araki & Kei-ichiro Ishiguro, 2023. "STRA8–RB interaction is required for timely entry of meiosis in mouse female germ cells," Nature Communications, Nature, vol. 14(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:529:y:2016:i:7586:d:10.1038_nature16480. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.