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Tet1 controls meiosis by regulating meiotic gene expression

Author

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  • Shinpei Yamaguchi

    (Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Kwonho Hong

    (Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Rui Liu

    (University of California at San Diego)

  • Li Shen

    (Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Azusa Inoue

    (Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA)

  • Dinh Diep

    (University of California at San Diego)

  • Kun Zhang

    (University of California at San Diego)

  • Yi Zhang

    (Howard Hughes Medical Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Harvard Stem Cell Institute, Harvard Medical School, WAB-149G, 200 Longwood Avenue, Boston, Massachusetts 02115, USA)

Abstract

A loss-of-function approach in mice is used to show that the methylcytosine dioxygenase Tet1 has a role in regulating meiosis and meiotic gene activation in female germ cells; Tet1 deficiency does not greatly affect genome-wide demethylation but has a more specific effect on the expression of a subset of meiotic genes.

Suggested Citation

  • Shinpei Yamaguchi & Kwonho Hong & Rui Liu & Li Shen & Azusa Inoue & Dinh Diep & Kun Zhang & Yi Zhang, 2012. "Tet1 controls meiosis by regulating meiotic gene expression," Nature, Nature, vol. 492(7429), pages 443-447, December.
    • Handle: RePEc:nat:nature:v:492:y:2012:i:7429:d:10.1038_nature11709
    DOI: 10.1038/nature11709
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    Cited by:

    1. Shengyong Yu & Chunhua Zhou & Jiangping He & Zhaokai Yao & Xingnan Huang & Bowen Rong & Hong Zhu & Shijie Wang & Shuyan Chen & Xialian Wang & Baomei Cai & Guoqing Zhao & Yuhan Chen & Lizhan Xiao & He , 2022. "BMP4 drives primed to naïve transition through PGC-like state," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Ryuki Shimada & Yuzuru Kato & Naoki Takeda & Sayoko Fujimura & Kei-ichiro Yasunaga & Shingo Usuki & Hitoshi Niwa & Kimi Araki & Kei-ichiro Ishiguro, 2023. "STRA8–RB interaction is required for timely entry of meiosis in mouse female germ cells," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    3. Mengwen Hu & Yu-Han Yeh & Yasuhisa Munakata & Hironori Abe & Akihiko Sakashita & So Maezawa & Miguel Vidal & Haruhiko Koseki & Neil Hunter & Richard M. Schultz & Satoshi H. Namekawa, 2022. "PRC1-mediated epigenetic programming is required to generate the ovarian reserve," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

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