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Presynaptic gating of monkey proprioceptive signals for proper motor action

Author

Listed:
  • Saeka Tomatsu

    (National Center of Neurology and Psychiatry
    National Institutes of Natural Sciences
    The Graduate University for Advanced Studies (SOKENDAI))

  • GeeHee Kim

    (National Center of Neurology and Psychiatry
    National Institutes of Natural Sciences
    The University of Tokyo)

  • Shinji Kubota

    (National Center of Neurology and Psychiatry)

  • Kazuhiko Seki

    (National Center of Neurology and Psychiatry
    The Graduate University for Advanced Studies (SOKENDAI)
    National Institutes of Natural Sciences)

Abstract

Our rich behavioural repertoire is supported by complicated synaptic connectivity in the central nervous system, which must be modulated to prevent behavioural control from being overwhelmed. For this modulation, presynaptic inhibition is an efficient mechanism because it can gate specific synaptic input without interfering with main circuit operations. Previously, we reported the task-dependent presynaptic inhibition of the cutaneous afferent input to the spinal cord in behaving monkeys. Here, we report presynaptic inhibition of the proprioceptive afferent input. We found that the input from shortened muscles is transiently facilitated, whereas that from lengthened muscles is persistently reduced. This presynaptic inhibition could be generated by cortical signals because it started before movement onset, and its size was correlated with the performance of stable motor output. Our findings demonstrate that presynaptic inhibition acts as a dynamic filter of proprioceptive signals, enabling the integration of task-relevant signals into spinal circuits.

Suggested Citation

  • Saeka Tomatsu & GeeHee Kim & Shinji Kubota & Kazuhiko Seki, 2023. "Presynaptic gating of monkey proprioceptive signals for proper motor action," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42077-w
    DOI: 10.1038/s41467-023-42077-w
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    References listed on IDEAS

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    1. Yuanyuan Liu & Alban Latremoliere & Xinjian Li & Zicong Zhang & Mengying Chen & Xuhua Wang & Chao Fang & Junjie Zhu & Chloe Alexandre & Zhongyang Gao & Bo Chen & Xin Ding & Jin-Yong Zhou & Yiming Zhan, 2018. "Touch and tactile neuropathic pain sensitivity are set by corticospinal projections," Nature, Nature, vol. 561(7724), pages 547-550, September.
    2. Yifat Prut & Eberhard E. Fetz, 1999. "Primate spinal interneurons show pre-movement instructed delay activity," Nature, Nature, vol. 401(6753), pages 590-594, October.
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