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Primate spinal interneurons show pre-movement instructed delay activity

Author

Listed:
  • Yifat Prut

    (Box 357330, University of Washington)

  • Eberhard E. Fetz

    (Box 357330, University of Washington)

Abstract

Preparatory changes in neural activity before the execution of a movement have been documented in tasks that involve an instructed delay period (an interval between a transient instruction cue and a subsequently triggered movement). Such preparatory activity occurs in many motor centres in the brain, including the primary motor cortex1,2,3,4,5,6, premotor cortex7,8,9, supplementary motor area6,10,11 and basal ganglia6,12,13. Activity during the instructed delay period reflects movement planning, as it correlates with parameters of the cue and the subsequent movement (such as direction and extent5,6,9), although it occurs well before muscle activity. How such delay-period activity shapes the ensuing motor action remains unknown. Here we show that spinal interneurons also exhibit early pre-movement delay activity that often differs from their responses during the subsequent muscle activity. This delay activity resembles the set-related activity found in various supraspinal areas, indicating that movement preparation may occur simultaneously over widely distributed regions, including spinal levels. Our results also suggest that two processes occur in the spinal circuitry during this delay period: the motor network is primed with rate changes in the same direction as subsequent movement-related activity; and a superimposed global inhibition suppresses the expression of this activity in muscles.

Suggested Citation

  • Yifat Prut & Eberhard E. Fetz, 1999. "Primate spinal interneurons show pre-movement instructed delay activity," Nature, Nature, vol. 401(6753), pages 590-594, October.
  • Handle: RePEc:nat:nature:v:401:y:1999:i:6753:d:10.1038_44145
    DOI: 10.1038/44145
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    Cited by:

    1. Saeka Tomatsu & GeeHee Kim & Shinji Kubota & Kazuhiko Seki, 2023. "Presynaptic gating of monkey proprioceptive signals for proper motor action," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Tanner C Dixon & Christina M Merrick & Joni D Wallis & Richard B Ivry & Jose M Carmena, 2021. "Hybrid dedicated and distributed coding in PMd/M1 provides separation and interaction of bilateral arm signals," PLOS Computational Biology, Public Library of Science, vol. 17(11), pages 1-35, November.
    3. Huimin Li & Jianle Lin & Shuxin Lin & Haojie Zhong & Bowei Jiang & Xinghui Liu & Weisheng Wu & Weiwei Li & Emad Iranmanesh & Zhongyi Zhou & Wenjun Li & Kai Wang, 2024. "A bioinspired tactile scanner for computer haptics," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    4. Michael Kennefick & Dana Maslovat & Anthony N Carlsen, 2014. "The Time Course of Corticospinal Excitability during a Simple Reaction Time Task," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-7, November.

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