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CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types

Author

Listed:
  • Leandro Barros

    (Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz)

  • Daryna Piontkivska

    (Instituto de Tecnologia Química e Biológica António Xavier, Av. da República)

  • Patrícia Figueiredo-Campos

    (Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz)

  • Júlia Fanczal

    (Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz)

  • Sofia Pereira Ribeiro

    (Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz)

  • Marta Baptista

    (Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz)

  • Silvia Ariotti

    (Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz)

  • Nuno Santos

    (Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6
    The Francis Crick Institute)

  • Maria João Amorim

    (Instituto Gulbenkian de Ciência, Rua da Quinta Grande 6
    Universidade Católica Portuguesa, Católica Médical School, Católica Biomedical Research Centre)

  • Cristina Silva Pereira

    (Instituto de Tecnologia Química e Biológica António Xavier, Av. da República)

  • Marc Veldhoen

    (Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz)

  • Cristina Ferreira

    (Faculdade de Medicina da Universidade de Lisboa, Av. Professor Egas Moniz)

Abstract

Immunological memory is critical for immune protection, particularly at epithelial sites, which are under constant risk of pathogen invasions. To counter invading pathogens, CD8+ memory T cells develop at the location of infection: tissue-resident memory T cells (TRM). CD8+ T-cell responses are associated with type-1 infections and type-1 regulatory T cells (TREG) are important for CD8+ T-cell development, however, if CD8+ TRM cells develop under other infection types and require immune type-specific TREG cells is unknown. We used three distinct lung infection models, to show that type-2 helminth infection does not establish CD8+ TRM cells. Intracellular (type-1) and extracellular (type-3) infections do and rely on the recruitment of response type-matching TREG population contributing transforming growth factor-β. Nevertheless, type-1 TREG cells remain the most important population for TRM cell development. Once established, TRM cells maintain their immune type profile. These results may have implications in the development of vaccines inducing CD8+ TRM cells.

Suggested Citation

  • Leandro Barros & Daryna Piontkivska & Patrícia Figueiredo-Campos & Júlia Fanczal & Sofia Pereira Ribeiro & Marta Baptista & Silvia Ariotti & Nuno Santos & Maria João Amorim & Cristina Silva Pereira & , 2023. "CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41364-w
    DOI: 10.1038/s41467-023-41364-w
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    References listed on IDEAS

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    1. R. Lee Reinhardt & Alexander Khoruts & Rebecca Merica & Traci Zell & Marc K. Jenkins, 2001. "Visualizing the generation of memory CD4 T cells in the whole body," Nature, Nature, vol. 410(6824), pages 101-105, March.
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