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FoxP3+ regulatory CD4 T cells control the generation of functional CD8 memory

Author

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  • M.G. de Goër de Herve

    (INSERM U-1012, Faculté de Médecine Paris-Sud, Université Paris Sud
    Hôpitaux Universitaires Paris-Sud, AP-HP)

  • S. Jaafoura

    (INSERM U-1012, Faculté de Médecine Paris-Sud, Université Paris Sud
    Hôpitaux Universitaires Paris-Sud, AP-HP)

  • M. Vallée

    (INSERM U-1012, Faculté de Médecine Paris-Sud, Université Paris Sud
    Hôpitaux Universitaires Paris-Sud, AP-HP)

  • Y. Taoufik

    (INSERM U-1012, Faculté de Médecine Paris-Sud, Université Paris Sud
    Hôpitaux Universitaires Paris-Sud, AP-HP)

Abstract

During the primary immune response, CD8 memory emerges from an environment of strong immune activation. The FoxP3+ regulatory CD4 T-cell subset (Treg) is known as a key suppressive component of the immune system. Here we report that Tregs are required for the generation of functional CD8 memory. In the absence of Tregs during priming, the resulting memory cells proliferate poorly and fail to differentiate into functional cytotoxic secondary effectors following antigen reactivation. We find that the Tregs act early, during the expansion phase of primary CD8 effectors, by fine tuning interleukin-2 exposure of CD8 memory precursors. This crucial new role of Tregs has implications for optimal vaccine development.

Suggested Citation

  • M.G. de Goër de Herve & S. Jaafoura & M. Vallée & Y. Taoufik, 2012. "FoxP3+ regulatory CD4 T cells control the generation of functional CD8 memory," Nature Communications, Nature, vol. 3(1), pages 1-10, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1992
    DOI: 10.1038/ncomms1992
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    Cited by:

    1. Leandro Barros & Daryna Piontkivska & Patrícia Figueiredo-Campos & Júlia Fanczal & Sofia Pereira Ribeiro & Marta Baptista & Silvia Ariotti & Nuno Santos & Maria João Amorim & Cristina Silva Pereira & , 2023. "CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types," Nature Communications, Nature, vol. 14(1), pages 1-13, December.

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