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Stability and function of regulatory T cells expressing the transcription factor T-bet

Author

Listed:
  • Andrew G. Levine

    (Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center)

  • Alejandra Mendoza

    (Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center)

  • Saskia Hemmers

    (Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center)

  • Bruno Moltedo

    (Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center)

  • Rachel E. Niec

    (Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center)

  • Michail Schizas

    (Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center)

  • Beatrice E. Hoyos

    (Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center)

  • Ekaterina V. Putintseva

    (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
    Central European Institute of Technology, Masaryk University)

  • Ashutosh Chaudhry

    (Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center)

  • Stanislav Dikiy

    (Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center)

  • Sho Fujisawa

    (Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center)

  • Dmitriy M. Chudakov

    (Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS
    Central European Institute of Technology, Masaryk University
    Pirogov Russian National Research Medical University)

  • Piper M. Treuting

    (University of Washington School of Medicine)

  • Alexander Y. Rudensky

    (Howard Hughes Medical Institute, Immunology Program, and Ludwig Center, Memorial Sloan Kettering Cancer Center)

Abstract

Regulatory T cells expressing the transcription factor T-bet selectively suppress TH1 and CD8 T cells, but not TH2 or TH17 activation and associated autoimmunity.

Suggested Citation

  • Andrew G. Levine & Alejandra Mendoza & Saskia Hemmers & Bruno Moltedo & Rachel E. Niec & Michail Schizas & Beatrice E. Hoyos & Ekaterina V. Putintseva & Ashutosh Chaudhry & Stanislav Dikiy & Sho Fujis, 2017. "Stability and function of regulatory T cells expressing the transcription factor T-bet," Nature, Nature, vol. 546(7658), pages 421-425, June.
    • Handle: RePEc:nat:nature:v:546:y:2017:i:7658:d:10.1038_nature22360
    DOI: 10.1038/nature22360
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    Cited by:

    1. Leandro Barros & Daryna Piontkivska & Patrícia Figueiredo-Campos & Júlia Fanczal & Sofia Pereira Ribeiro & Marta Baptista & Silvia Ariotti & Nuno Santos & Maria João Amorim & Cristina Silva Pereira & , 2023. "CD8+ tissue-resident memory T-cell development depends on infection-matching regulatory T-cell types," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    2. Mikhael D. Manurung & Friederike Sonnet & Marie-Astrid Hoogerwerf & Jacqueline J. Janse & Yvonne Kruize & Laura de Bes-Roeleveld & Marion König & Alex Loukas & Benjamin G. Dewals & Taniawati Supali & , 2024. "Controlled human hookworm infection remodels plasmacytoid dendritic cells and regulatory T cells towards profiles seen in natural infections in endemic areas," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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