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Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles

Author

Listed:
  • Niels Berg

    (Leiden University Medical Center
    Lund University)

  • Mar Rodríguez-Girondo

    (Leiden University Medical Center)

  • Ingrid K. Dijk

    (Lund University)

  • P. Eline Slagboom

    (Leiden University Medical Center
    Max Planck Institute for Biology of Ageing)

  • Marian Beekman

    (Leiden University Medical Center)

Abstract

Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants with each additional long-lived family member. Here we investigate whether the healthspan in such families follows a similar quantitative pattern using three-generational data from two databases, LLS (Netherlands), and SEDD (Sweden). We study healthspan in 2143 families containing index persons with 26 follow-up years and two ancestral generations, comprising 17,539 persons. Our results provide strong evidence that an increasing number of long-lived ancestors associates with up to a decade of healthspan extension. Further evidence indicates that members of long-lived families have a delayed onset of medication use, multimorbidity and, in mid-life, healthier metabolomic profiles than their partners. We conclude that both lifespan and healthspan are quantitatively linked to ancestral longevity, making family data invaluable to identify protective mechanisms of multimorbidity.

Suggested Citation

  • Niels Berg & Mar Rodríguez-Girondo & Ingrid K. Dijk & P. Eline Slagboom & Marian Beekman, 2023. "Increasing number of long-lived ancestors marks a decade of healthspan extension and healthier metabolomics profiles," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40245-6
    DOI: 10.1038/s41467-023-40245-6
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    References listed on IDEAS

    as
    1. Christian Fuchsberger & Jason Flannick & Tanya M. Teslovich & Anubha Mahajan & Vineeta Agarwala & Kyle J. Gaulton & Clement Ma & Pierre Fontanillas & Loukas Moutsianas & Davis J. McCarthy & Manuel A. , 2016. "The genetic architecture of type 2 diabetes," Nature, Nature, vol. 536(7614), pages 41-47, August.
    2. Niels Berg & Mar Rodríguez-Girondo & Ingrid K. Dijk & Rick J. Mourits & Kees Mandemakers & Angelique A. P. O. Janssens & Marian Beekman & Ken R. Smith & P. Eline Slagboom, 2019. "Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
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