Genetic variation in the immunoglobulin heavy chain locus shapes the human antibody repertoire
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DOI: 10.1038/s41467-023-40070-x
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- Yik Andy Yeung & Davide Foletti & Xiaodi Deng & Yasmina Abdiche & Pavel Strop & Jacob Glanville & Steven Pitts & Kevin Lindquist & Purnima D. Sundar & Marina Sirota & Adela Hasa-Moreno & Amber Pham & , 2016. "Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire," Nature Communications, Nature, vol. 7(1), pages 1-14, December.
- Quentin Marcou & Thierry Mora & Aleksandra M. Walczak, 2018. "High-throughput immune repertoire analysis with IGoR," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
- Moriah Gidoni & Omri Snir & Ayelet Peres & Pazit Polak & Ida Lindeman & Ivana Mikocziova & Vikas Kumar Sarna & Knut E. A. Lundin & Christopher Clouser & Francois Vigneault & Andrew M. Collins & Ludvig, 2019. "Mosaic deletion patterns of the human antibody heavy chain gene locus shown by Bayesian haplotyping," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
- Zhaoqing Ba & Jiangman Lou & Adam Yongxin Ye & Hai-Qiang Dai & Edward W. Dring & Sherry G. Lin & Suvi Jain & Nia Kyritsis & Kyong-Rim Kieffer-Kwon & Rafael Casellas & Frederick W. Alt, 2020. "CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning," Nature, Nature, vol. 586(7828), pages 305-310, October.
- Kyle Kai-How Farh & Alexander Marson & Jiang Zhu & Markus Kleinewietfeld & William J. Housley & Samantha Beik & Noam Shoresh & Holly Whitton & Russell J. H. Ryan & Alexander A. Shishkin & Meital Hatan, 2015. "Genetic and epigenetic fine mapping of causal autoimmune disease variants," Nature, Nature, vol. 518(7539), pages 337-343, February.
- Tom Parks & Mariana M. Mirabel & Joseph Kado & Kathryn Auckland & Jaroslaw Nowak & Anna Rautanen & Alexander J. Mentzer & Eloi Marijon & Xavier Jouven & Mai Ling Perman & Tuliana Cua & John K. Kauwe &, 2017. "Association between a common immunoglobulin heavy chain allele and rheumatic heart disease risk in Oceania," Nature Communications, Nature, vol. 8(1), pages 1-10, August.
- Florian Rubelt & Christopher R. Bolen & Helen M. McGuire & Jason A. Vander Heiden & Daniel Gadala-Maria & Mikhail Levin & Ghia M. Euskirchen & Murad R. Mamedov & Gary E. Swan & Cornelia L. Dekker & Li, 2016. "Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells," Nature Communications, Nature, vol. 7(1), pages 1-12, June.
- Daniel Felsky & Tina Roostaei & Kwangsik Nho & Shannon L. Risacher & Elizabeth M. Bradshaw & Vlad Petyuk & Julie A. Schneider & Andrew Saykin & David A. Bennett & Philip L. De Jager, 2019. "Neuropathological correlates and genetic architecture of microglial activation in elderly human brain," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
- Louisa Hill & Anja Ebert & Markus Jaritz & Gordana Wutz & Kota Nagasaka & Hiromi Tagoh & Daniela Kostanova-Poliakova & Karina Schindler & Qiong Sun & Peter Bönelt & Maria Fischer & Jan-Michael Peters , 2020. "Wapl repression by Pax5 promotes V gene recombination by Igh loop extrusion," Nature, Nature, vol. 584(7819), pages 142-147, August.
- Michal Levy-Sakin & Steven Pastor & Yulia Mostovoy & Le Li & Alden K. Y. Leung & Jennifer McCaffrey & Eleanor Young & Ernest T. Lam & Alex R. Hastie & Karen H. Y. Wong & Claire Y. L. Chung & Walfred M, 2019. "Genome maps across 26 human populations reveal population-specific patterns of structural variation," Nature Communications, Nature, vol. 10(1), pages 1-14, December.
- Carles A. Boix & Benjamin T. James & Yongjin P. Park & Wouter Meuleman & Manolis Kellis, 2021. "Regulatory genomic circuitry of human disease loci by integrative epigenomics," Nature, Nature, vol. 590(7845), pages 300-307, February.
- Benjamin B. Sun & Joseph C. Maranville & James E. Peters & David Stacey & James R. Staley & James Blackshaw & Stephen Burgess & Tao Jiang & Ellie Paige & Praveen Surendran & Clare Oliver-Williams & Mi, 2018. "Genomic atlas of the human plasma proteome," Nature, Nature, vol. 558(7708), pages 73-79, June.
- Khalid H. Bhat & Saurabh Priyadarshi & Sarah Naiyer & Xinyan Qu & Hammad Farooq & Eden Kleiman & Jeffery Xu & Xue Lei & Jose F. Cantillo & Robert Wuerffel & Nicole Baumgarth & Jie Liang & Ann J. Feene, 2023. "An Igh distal enhancer modulates antigen receptor diversity by determining locus conformation," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
- Bryan Briney & Anne Inderbitzin & Collin Joyce & Dennis R. Burton, 2019. "Commonality despite exceptional diversity in the baseline human antibody repertoire," Nature, Nature, vol. 566(7744), pages 393-397, February.
- Chunguang Guo & Hye Suk Yoon & Andrew Franklin & Suvi Jain & Anja Ebert & Hwei-Ling Cheng & Erica Hansen & Orion Despo & Claudia Bossen & Christian Vettermann & Jamie G. Bates & Nicholas Richards & Da, 2011. "CTCF-binding elements mediate control of V(D)J recombination," Nature, Nature, vol. 477(7365), pages 424-430, September.
- Cinque Soto & Robin G. Bombardi & Andre Branchizio & Nurgun Kose & Pranathi Matta & Alexander M. Sevy & Robert S. Sinkovits & Pavlo Gilchuk & Jessica A. Finn & James E. Crowe, 2019. "High frequency of shared clonotypes in human B cell receptor repertoires," Nature, Nature, vol. 566(7744), pages 398-402, February.
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