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Roles of adenine methylation in the physiology of Lacticaseibacillus paracasei

Author

Listed:
  • Jie Zhao

    (Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University)

  • Meng Zhang

    (Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University)

  • Wenyan Hui

    (Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University)

  • Yue Zhang

    (Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University)

  • Jing Wang

    (Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University)

  • Shaojing Wang

    (College of Life Sciences, Nankai University)

  • Lai-Yu Kwok

    (Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University)

  • Jian Kong

    (Shandong University)

  • Heping Zhang

    (Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University)

  • Wenyi Zhang

    (Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University
    Inner Mongolia Agricultural University)

Abstract

Lacticaseibacillus paracasei is an economically important bacterial species, used in the food industry and as a probiotic. Here, we investigate the roles of N6-methyladenine (6mA) modification in L. paracasei using multi-omics and high-throughput chromosome conformation capture (Hi-C) analyses. The distribution of 6mA-modified sites varies across the genomes of 28 strains, and appears to be enriched near genes involved in carbohydrate metabolism. A pglX mutant, defective in 6mA modification, shows transcriptomic alterations but only modest changes in growth and genomic spatial organization.

Suggested Citation

  • Jie Zhao & Meng Zhang & Wenyan Hui & Yue Zhang & Jing Wang & Shaojing Wang & Lai-Yu Kwok & Jian Kong & Heping Zhang & Wenyi Zhang, 2023. "Roles of adenine methylation in the physiology of Lacticaseibacillus paracasei," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38291-1
    DOI: 10.1038/s41467-023-38291-1
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    1. Zhihong Sun & Hugh M. B. Harris & Angela McCann & Chenyi Guo & Silvia Argimón & Wenyi Zhang & Xianwei Yang & Ian B Jeffery & Jakki C. Cooney & Todd F. Kagawa & Wenjun Liu & Yuqin Song & Elisa Salvetti, 2015. "Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera," Nature Communications, Nature, vol. 6(1), pages 1-13, November.
    2. Emily Crane & Qian Bian & Rachel Patton McCord & Bryan R. Lajoie & Bayly S. Wheeler & Edward J. Ralston & Satoru Uzawa & Job Dekker & Barbara J. Meyer, 2015. "Condensin-driven remodelling of X chromosome topology during dosage compensation," Nature, Nature, vol. 523(7559), pages 240-244, July.
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    1. Carlos Lax & Stephen J. Mondo & Macario Osorio-Concepción & Anna Muszewska & María Corrochano-Luque & Gabriel Gutiérrez & Robert Riley & Anna Lipzen & Jie Guo & Hope Hundley & Mojgan Amirebrahimi & Vi, 2024. "Symmetric and asymmetric DNA N6-adenine methylation regulates different biological responses in Mucorales," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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