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Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice

Author

Listed:
  • Bin Yu

    (Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation
    Zhujiang Hospital, Southern Medical University)

  • Hekai Li

    (Zhujiang Hospital, Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Southern Medical University)

  • Zhaowenbin Zhang

    (Wenzhou Institute, Zhejiang Engineering Research Center for Tissue Repair Materials, University of Chinese Academy of Sciences
    Shanghai Institute of Ceramics, Chinese Academy of Sciences
    The First Affiliated Hospital of Wenzhou Medical University)

  • Peier Chen

    (Zhujiang Hospital, Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Southern Medical University)

  • Ling Wang

    (Southern Medical University)

  • Xianglin Fan

    (Zhujiang Hospital, Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Southern Medical University)

  • Xiaodong Ning

    (Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation)

  • Yuxuan Pan

    (Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation)

  • Feiran Zhou

    (Zhujiang Hospital, Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Southern Medical University)

  • Xinyi Hu

    (Zhujiang Hospital, Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Southern Medical University)

  • Jiang Chang

    (Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation
    Wenzhou Institute, Zhejiang Engineering Research Center for Tissue Repair Materials, University of Chinese Academy of Sciences
    Shanghai Institute of Ceramics, Chinese Academy of Sciences
    The First Affiliated Hospital of Wenzhou Medical University)

  • Caiwen Ou

    (Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation
    Zhujiang Hospital, Southern Medical University
    Zhujiang Hospital, Guangdong Provincial Biomedical Engineering Technology Research Center for Cardiovascular Disease, Southern Medical University)

Abstract

Extracellular vesicles have shown good potential in disease treatments including ischemic injury such as myocardial infarction. However, the efficient production of highly active extracellular vesicles is one of the critical limitations for their clinical applications. Here, we demonstrate a biomaterial-based approach to prepare high amounts of extracellular vesicles with high bioactivity from endothelial progenitor cells (EPCs) by stimulation with silicate ions derived from bioactive silicate ceramics. We further show that hydrogel microspheres containing engineered extracellular vesicles are highly effective in the treatment of myocardial infarction in male mice by significantly enhancing angiogenesis. This therapeutic effect is attributed to significantly enhanced revascularization by the high content of miR-126a-3p and angiogenic factors such as VEGF and SDF-1, CXCR4 and eNOS in engineered extracellular vesicles, which not only activate endothelial cells but also recruit EPCs from the circulatory system.

Suggested Citation

  • Bin Yu & Hekai Li & Zhaowenbin Zhang & Peier Chen & Ling Wang & Xianglin Fan & Xiaodong Ning & Yuxuan Pan & Feiran Zhou & Xinyi Hu & Jiang Chang & Caiwen Ou, 2023. "Extracellular vesicles engineering by silicates-activated endothelial progenitor cells for myocardial infarction treatment in male mice," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37832-y
    DOI: 10.1038/s41467-023-37832-y
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    References listed on IDEAS

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    1. Carolina Villarroya-Beltri & Cristina Gutiérrez-Vázquez & Fátima Sánchez-Cabo & Daniel Pérez-Hernández & Jesús Vázquez & Noa Martin-Cofreces & Dannys Jorge Martinez-Herrera & Alberto Pascual-Montano &, 2013. "Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs," Nature Communications, Nature, vol. 4(1), pages 1-10, December.
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    Cited by:

    1. Doyeon Koo & Xiao Cheng & Shreya Udani & Sevana Baghdasarian & Dashuai Zhu & Junlang Li & Brian Hall & Natalie Tsubamoto & Shiqi Hu & Jina Ko & Ke Cheng & Dino Di Carlo, 2024. "Optimizing cell therapy by sorting cells with high extracellular vesicle secretion," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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