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Amyloid-polysaccharide interfacial coacervates as therapeutic materials

Author

Listed:
  • Mohammad Peydayesh

    (ETH Zurich, Department of Health Sciences and Technology)

  • Sabrina Kistler

    (ETH Zurich, Department of Materials)

  • Jiangtao Zhou

    (ETH Zurich, Department of Health Sciences and Technology)

  • Viviane Lutz-Bueno

    (ETH Zurich, Department of Health Sciences and Technology
    Paul Scherrer Institute PSI)

  • Francesca Damiani Victorelli

    (ETH Zurich, Department of Health Sciences and Technology)

  • Andréia Bagliotti Meneguin

    (School of Pharmaceutical Sciences, São Paulo State University)

  • Larissa Spósito

    (School of Pharmaceutical Sciences, São Paulo State University
    São Paulo State University)

  • Tais Maria Bauab

    (São Paulo State University)

  • Marlus Chorilli

    (School of Pharmaceutical Sciences, São Paulo State University)

  • Raffaele Mezzenga

    (ETH Zurich, Department of Health Sciences and Technology
    ETH Zurich, Department of Materials)

Abstract

Coacervation via liquid-liquid phase separation provides an excellent opportunity to address the challenges of designing nanostructured biomaterials with multiple functionalities. Protein-polysaccharide coacervates, in particular, offer an appealing strategy to target biomaterial scaffolds, but these systems suffer from the low mechanical and chemical stabilities of protein-based condensates. Here we overcome these limitations by transforming native proteins into amyloid fibrils and demonstrate that the coacervation of cationic protein amyloids and anionic linear polysaccharides results in the interfacial self-assembly of biomaterials with precise control of their structure and properties. The coacervates present a highly ordered asymmetric architecture with amyloid fibrils on one side and the polysaccharide on the other. We demonstrate the excellent performance of these coacervates for gastric ulcer protection by validating via an in vivo assay their therapeutic effect as engineered microparticles. These results point at amyloid-polysaccharides coacervates as an original and effective biomaterial for multiple uses in internal medicine.

Suggested Citation

  • Mohammad Peydayesh & Sabrina Kistler & Jiangtao Zhou & Viviane Lutz-Bueno & Francesca Damiani Victorelli & Andréia Bagliotti Meneguin & Larissa Spósito & Tais Maria Bauab & Marlus Chorilli & Raffaele , 2023. "Amyloid-polysaccharide interfacial coacervates as therapeutic materials," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37629-z
    DOI: 10.1038/s41467-023-37629-z
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    References listed on IDEAS

    as
    1. F. S. Ruggeri & G. Longo & S. Faggiano & E. Lipiec & A. Pastore & G. Dietler, 2015. "Infrared nanospectroscopy characterization of oligomeric and fibrillar aggregates during amyloid formation," Nature Communications, Nature, vol. 6(1), pages 1-9, November.
    2. Mohammad Peydayesh & Raffaele Mezzenga, 2021. "Protein nanofibrils for next generation sustainable water purification," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    3. Roland Riek & David S. Eisenberg, 2016. "The activities of amyloids from a structural perspective," Nature, Nature, vol. 539(7628), pages 227-235, November.
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    1. Jae-Hyeon Lee & Hansol Lim & Gaeun Ma & Seho Kweon & Seong Jin Park & Minho Seo & Jun-Hyuck Lee & Seong-Bin Yang & Han-Gil Jeong & Jooho Park, 2024. "Nano-anticoagulant based on carrier-free low molecular weight heparin and octadecylamine with an albumin shuttling effect," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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