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White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control

Author

Listed:
  • Jiefeng Jiang

    (University of Iowa
    University of Iowa
    University of Iowa)

  • Joel Bruss

    (Carver College of Medicine
    Carver College of Medicine)

  • Woo-Tek Lee

    (University of Iowa
    University of Iowa
    University of Iowa)

  • Daniel Tranel

    (University of Iowa
    University of Iowa
    Carver College of Medicine)

  • Aaron D. Boes

    (University of Iowa
    Carver College of Medicine
    Carver College of Medicine
    Carver College of Medicine)

Abstract

Cognitive control modulates other cognitive functions to achieve internal goals and is important for adaptive behavior. Cognitive control is enabled by the neural computations distributed over cortical and subcortical areas. However, due to technical challenges in recording neural activity from the white matter, little is known about the anatomy of white matter tracts that coordinate the distributed neural computations that support cognitive control. Here, we leverage a large sample of human patients with focal brain lesions (n = 643) and investigate how lesion location and connectivity profiles account for variance in cognitive control performance. We find that lesions in white matter connecting left frontoparietal regions of the multiple demand network reliably predict deficits in cognitive control performance. These findings advance our understanding of the white matter correlates of cognitive control and provide an approach for incorporating network disconnection to predict deficits following lesions.

Suggested Citation

  • Jiefeng Jiang & Joel Bruss & Woo-Tek Lee & Daniel Tranel & Aaron D. Boes, 2023. "White matter disconnection of left multiple demand network is associated with post-lesion deficits in cognitive control," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37330-1
    DOI: 10.1038/s41467-023-37330-1
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    1. Matthew F. Glasser & Timothy S. Coalson & Emma C. Robinson & Carl D. Hacker & John Harwell & Essa Yacoub & Kamil Ugurbil & Jesper Andersson & Christian F. Beckmann & Mark Jenkinson & Stephen M. Smith , 2016. "A multi-modal parcellation of human cerebral cortex," Nature, Nature, vol. 536(7615), pages 171-178, August.
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