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A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination

Author

Listed:
  • Lihua Qiang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yong Zhang

    (Chinese Academy of Sciences)

  • Zehui Lei

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Zhe Lu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Shasha Tan

    (Chinese Academy of Sciences)

  • Pupu Ge

    (Chinese Academy of Sciences)

  • Qiyao Chai

    (Chinese Academy of Sciences)

  • Mengyuan Zhao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Xinwen Zhang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Bingxi Li

    (Chinese Academy of Sciences)

  • Yu Pang

    (Capital Medical University)

  • Lingqiang Zhang

    (Beijing Institute of Lifeomics)

  • Cui Hua Liu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Jing Wang

    (Chinese Academy of Sciences)

Abstract

Ferroptosis is a lipid peroxidation-driven and iron-dependent programmed cell death involved in multiple physical processes and various diseases. Emerging evidence suggests that several pathogens manipulate ferroptosis for their pathogenicity and dissemination, but the underlying molecular mechanisms remain elusive. Here, we identify that protein tyrosine phosphatase A (PtpA), an effector secreted by tuberculosis (TB)-causing pathogen Mycobacterium tuberculosis (Mtb), triggers ferroptosis to promote Mtb pathogenicity and dissemination. Mechanistically, PtpA, through its Cys11 site, interacts with host RanGDP to enter host cell nucleus. Then, the nuclear PtpA enhances asymmetric dimethylation of histone H3 arginine 2 (H3R2me2a) via targeting protein arginine methyltransferase 6 (PRMT6), thus inhibiting glutathione peroxidase 4 (GPX4) expression, eventually inducing ferroptosis to promote Mtb pathogenicity and dissemination. Taken together, our findings provide insights into molecular mechanisms of pathogen-induced ferroptosis, indicating a potential TB treatment via blocking Mtb PtpA-host PRMT6 interface to target GPX4-dependent ferroptosis.

Suggested Citation

  • Lihua Qiang & Yong Zhang & Zehui Lei & Zhe Lu & Shasha Tan & Pupu Ge & Qiyao Chai & Mengyuan Zhao & Xinwen Zhang & Bingxi Li & Yu Pang & Lingqiang Zhang & Cui Hua Liu & Jing Wang, 2023. "A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37148-x
    DOI: 10.1038/s41467-023-37148-x
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    References listed on IDEAS

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    1. Jing Wang & Pupu Ge & Lihua Qiang & Feng Tian & Dongdong Zhao & Qiyao Chai & Mingzhao Zhu & Rongbin Zhou & Guangxun Meng & Yoichiro Iwakura & George Fu Gao & Cui Hua Liu, 2017. "The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation," Nature Communications, Nature, vol. 8(1), pages 1-16, December.
    2. Imtiyaz Yaseen & Prabhjot Kaur & Vinay Kumar Nandicoori & Sanjeev Khosla, 2015. "Mycobacteria modulate host epigenetic machinery by Rv1988 methylation of a non-tail arginine of histone H3," Nature Communications, Nature, vol. 6(1), pages 1-13, December.
    3. Zhennan Shi & Nathchar Naowarojna & Zijian Pan & Yilong Zou, 2021. "Multifaceted mechanisms mediating cystine starvation-induced ferroptosis," Nature Communications, Nature, vol. 12(1), pages 1-4, December.
    4. Ernesto Guccione & Christian Bassi & Fabio Casadio & Francesca Martinato & Matteo Cesaroni & Henning Schuchlautz & Bernhard Lüscher & Bruno Amati, 2007. "Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive," Nature, Nature, vol. 449(7164), pages 933-937, October.
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    Cited by:

    1. Boyi Gan, 2023. "Ferroptosis hijacking by Mycobacterium tuberculosis," Nature Communications, Nature, vol. 14(1), pages 1-3, December.

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