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The Bidirectional Relationship between Pulmonary Tuberculosis and Lung Cancer

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  • Mădălina Preda

    (Marius Nasta Institute of Pneumology, 050159 Bucharest, Romania
    Microbiology, Parasitology and Virology Discipline, Department of Fundamental Sciences, Faculty of Midwives and Nursing, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
    These authors contributed equally to this work.)

  • Bogdan Cosmin Tănase

    (Department of Thoracic Surgery, Institute of Oncology “Prof. Dr. Al. Trestioreanu” Bucharest, 022328 Bucharest, Romania
    These authors contributed equally to this work.)

  • Daniela Luminița Zob

    (Department of Medical Oncology II, Institute of Oncology “Prof. Dr. Al. Trestioreanu” Bucharest, 022328 Bucharest, Romania
    These authors contributed equally to this work.)

  • Adelina Silvana Gheorghe

    (Department of Oncology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
    Department of Medical Oncology I, Institute of Oncology “Prof. Dr. Al. Trestioreanu” Bucharest, 022328 Bucharest, Romania
    These authors contributed equally to this work.)

  • Cristian Virgil Lungulescu

    (Department of Oncology, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania)

  • Elena Adriana Dumitrescu

    (Department of Oncology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania)

  • Dana Lucia Stănculeanu

    (Department of Oncology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
    Department of Medical Oncology I, Institute of Oncology “Prof. Dr. Al. Trestioreanu” Bucharest, 022328 Bucharest, Romania)

  • Loredana Sabina Cornelia Manolescu

    (Microbiology, Parasitology and Virology Discipline, Department of Fundamental Sciences, Faculty of Midwives and Nursing, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
    Department of Virology, Institute of Virology “Stefan S. Nicolau”, 030304 Bucharest, Romania)

  • Oana Popescu

    (Marius Nasta Institute of Pneumology, 050159 Bucharest, Romania)

  • Elmira Ibraim

    (Marius Nasta Institute of Pneumology, 050159 Bucharest, Romania)

  • Beatrice Mahler

    (Marius Nasta Institute of Pneumology, 050159 Bucharest, Romania
    Pneumo-Phthisiology II Discipline, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania)

Abstract

Lung cancer and pulmonary tuberculosis are two significant public health problems that continue to take millions of lives each year. They may have similar symptoms and, in some cases, are diagnosed simultaneously or may have a causal relationship. In tuberculosis disease, the chronic inflammation, different produced molecules, genomic changes, and fibrosis are believed to be important factors that may promote carcinogenesis. As a reverse reaction, the development of carcinogenesis and the treatment may induce the reactivation of latent tuberculosis infection. Moreover, the recently used checkpoint inhibitors are a debatable subject since they help treat lung cancer but may lead to the reactivation of pulmonary tuberculosis and checkpoint-induced pneumonitis. Pulmonary rehabilitation is an effective intervention in post-tuberculosis patients and lung cancer patients and should be recommended to improve outcomes in these pathologies.

Suggested Citation

  • Mădălina Preda & Bogdan Cosmin Tănase & Daniela Luminița Zob & Adelina Silvana Gheorghe & Cristian Virgil Lungulescu & Elena Adriana Dumitrescu & Dana Lucia Stănculeanu & Loredana Sabina Cornelia Mano, 2023. "The Bidirectional Relationship between Pulmonary Tuberculosis and Lung Cancer," IJERPH, MDPI, vol. 20(2), pages 1-13, January.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:2:p:1282-:d:1031525
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    References listed on IDEAS

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    1. Jing Wang & Pupu Ge & Lihua Qiang & Feng Tian & Dongdong Zhao & Qiyao Chai & Mingzhao Zhu & Rongbin Zhou & Guangxun Meng & Yoichiro Iwakura & George Fu Gao & Cui Hua Liu, 2017. "The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation," Nature Communications, Nature, vol. 8(1), pages 1-16, December.
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