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An open label, non-randomized study assessing a prebiotic fiber intervention in a small cohort of Parkinson’s disease participants

Author

Listed:
  • Deborah A. Hall

    (Rush University Medical Center)

  • Robin M. Voigt

    (Rush University Medical Center
    Rush University Medical Center
    Rush University Medical Center)

  • Thaisa M. Cantu-Jungles

    (Rush University Medical Center
    Purdue University)

  • Bruce Hamaker

    (Rush University Medical Center
    Purdue University)

  • Phillip A. Engen

    (Rush University Medical Center)

  • Maliha Shaikh

    (Rush University Medical Center)

  • Shohreh Raeisi

    (Rush University Medical Center)

  • Stefan J. Green

    (Rush University Medical Center
    Rush University Medical Center
    Rush University Medical Center)

  • Ankur Naqib

    (Rush University Medical Center
    Rush University Medical Center)

  • Christopher B. Forsyth

    (Rush University Medical Center
    Rush University Medical Center
    Rush University Medical Center)

  • Tingting Chen

    (Purdue University
    Nanchang University)

  • Richard Manfready

    (Rush University Medical Center)

  • Bichun Ouyang

    (Rush University Medical Center)

  • Heather E. Rasmussen

    (Rush University Medical Center
    University of Nebraska)

  • Shahriar Sedghi

    (Mercer University)

  • Christopher G. Goetz

    (Rush University Medical Center)

  • Ali Keshavarzian

    (Rush University Medical Center
    Rush University Medical Center
    Rush University Medical Center
    Rush University Medical Center)

Abstract

A pro-inflammatory intestinal microbiome is characteristic of Parkinson’s disease (PD). Prebiotic fibers change the microbiome and this study sought to understand the utility of prebiotic fibers for use in PD patients. The first experiments demonstrate that fermentation of PD patient stool with prebiotic fibers increased the production of beneficial metabolites (short chain fatty acids, SCFA) and changed the microbiota demonstrating the capacity of PD microbiota to respond favorably to prebiotics. Subsequently, an open-label, non-randomized study was conducted in newly diagnosed, non-medicated (n = 10) and treated PD participants (n = 10) wherein the impact of 10 days of prebiotic intervention was evaluated. Outcomes demonstrate that the prebiotic intervention was well tolerated (primary outcome) and safe (secondary outcome) in PD participants and was associated with beneficial biological changes in the microbiota, SCFA, inflammation, and neurofilament light chain. Exploratory analyses indicate effects on clinically relevant outcomes. This proof-of-concept study offers the scientific rationale for placebo-controlled trials using prebiotic fibers in PD patients. ClinicalTrials.gov Identifier: NCT04512599.

Suggested Citation

  • Deborah A. Hall & Robin M. Voigt & Thaisa M. Cantu-Jungles & Bruce Hamaker & Phillip A. Engen & Maliha Shaikh & Shohreh Raeisi & Stefan J. Green & Ankur Naqib & Christopher B. Forsyth & Tingting Chen , 2023. "An open label, non-randomized study assessing a prebiotic fiber intervention in a small cohort of Parkinson’s disease participants," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36497-x
    DOI: 10.1038/s41467-023-36497-x
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    References listed on IDEAS

    as
    1. Kuan-Fu Chen & Chung-Hsien Chaou & Jing-Yi Jiang & Hsueh-Wen Yu & Yu-Hsiang Meng & Wei-Chen Tang & Chin-Chieh Wu, 2016. "Diagnostic Accuracy of Lipopolysaccharide-Binding Protein as Biomarker for Sepsis in Adult Patients: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-13, April.
    2. Sebastiaan P. Kessel & Alexandra K. Frye & Ahmed O. El-Gendy & Maria Castejon & Ali Keshavarzian & Gertjan Dijk & Sahar El Aidy, 2019. "Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson’s disease," Nature Communications, Nature, vol. 10(1), pages 1-11, December.
    3. Marti J. Anderson, 2006. "Distance-Based Tests for Homogeneity of Multivariate Dispersions," Biometrics, The International Biometric Society, vol. 62(1), pages 245-253, March.
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