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Diverse secondary metabolites are expressed in particle-associated and free-living microorganisms of the permanently anoxic Cariaco Basin

Author

Listed:
  • David Geller-McGrath

    (Woods Hole Oceanographic Institution)

  • Paraskevi Mara

    (Woods Hole Oceanographic Institution)

  • Gordon T. Taylor

    (Stony Brook University)

  • Elizabeth Suter

    (Stony Brook University
    Molloy College)

  • Virginia Edgcomb

    (Woods Hole Oceanographic Institution)

  • Maria Pachiadaki

    (Woods Hole Oceanographic Institution)

Abstract

Secondary metabolites play essential roles in ecological interactions and nutrient acquisition, and are of interest for their potential uses in medicine and biotechnology. Genome mining for biosynthetic gene clusters (BGCs) can be used for the discovery of new compounds. Here, we use metagenomics and metatranscriptomics to analyze BGCs in free-living and particle-associated microbial communities through the stratified water column of the Cariaco Basin, Venezuela. We recovered 565 bacterial and archaeal metagenome-assembled genomes (MAGs) and identified 1154 diverse BGCs. We show that differences in water redox potential and microbial lifestyle (particle-associated vs. free-living) are associated with variations in the predicted composition and production of secondary metabolites. Our results indicate that microbes, including understudied clades such as Planctomycetota, potentially produce a wide range of secondary metabolites in these anoxic/euxinic waters.

Suggested Citation

  • David Geller-McGrath & Paraskevi Mara & Gordon T. Taylor & Elizabeth Suter & Virginia Edgcomb & Maria Pachiadaki, 2023. "Diverse secondary metabolites are expressed in particle-associated and free-living microorganisms of the permanently anoxic Cariaco Basin," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36026-w
    DOI: 10.1038/s41467-023-36026-w
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    References listed on IDEAS

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    1. Kirstin Scherlach & Christian Hertweck, 2021. "Mining and unearthing hidden biosynthetic potential," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Sunke Schmidtko & Lothar Stramma & Martin Visbeck, 2017. "Decline in global oceanic oxygen content during the past five decades," Nature, Nature, vol. 542(7641), pages 335-339, February.
    3. Lucas Paoli & Hans-Joachim Ruscheweyh & Clarissa C. Forneris & Florian Hubrich & Satria Kautsar & Agneya Bhushan & Alessandro Lotti & Quentin Clayssen & Guillem Salazar & Alessio Milanese & Charlotte , 2022. "Biosynthetic potential of the global ocean microbiome," Nature, Nature, vol. 607(7917), pages 111-118, July.
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