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Mining and unearthing hidden biosynthetic potential

Author

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  • Kirstin Scherlach

    (Leibniz Institute for Natural Product Research and Infection Biology, HKI)

  • Christian Hertweck

    (Leibniz Institute for Natural Product Research and Infection Biology, HKI
    Friedrich Schiller University Jena)

Abstract

Genetically encoded small molecules (secondary metabolites) play eminent roles in ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical mediators often evade detection, and the discovery of novel entities is hampered by low production and high rediscovery rates. These limitations may be addressed by genome mining for biosynthetic gene clusters, thereby unveiling cryptic metabolic potential. The development of sophisticated data mining methods and genetic and analytical tools has enabled the discovery of an impressive array of previously overlooked natural products. This review shows the newest developments in the field, highlighting compound discovery from unconventional sources and microbiomes.

Suggested Citation

  • Kirstin Scherlach & Christian Hertweck, 2021. "Mining and unearthing hidden biosynthetic potential," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-24133-5
    DOI: 10.1038/s41467-021-24133-5
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    Cited by:

    1. Georges P. Schmartz & Jacqueline Rehner & Miriam J. Schuff & Leidy-Alejandra G. Molano & Sören L. Becker & Marcin Krawczyk & Azat Tagirdzhanov & Alexey Gurevich & Richard Francke & Rolf Müller & Veren, 2024. "Exploring microbial diversity and biosynthetic potential in zoo and wildlife animal microbiomes," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Jinfeng Li & Bao Chen & Zunyun Fu & Jingjing Mao & Lijun Liu & Xiaochen Chen & Mingyue Zheng & Chang-Yun Wang & Chengyuan Wang & Yue-Wei Guo & Baofu Xu, 2024. "Discovery of a terpene synthase synthesizing a nearly non-flexible eunicellane reveals the basis of flexibility," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    3. David Geller-McGrath & Paraskevi Mara & Gordon T. Taylor & Elizabeth Suter & Virginia Edgcomb & Maria Pachiadaki, 2023. "Diverse secondary metabolites are expressed in particle-associated and free-living microorganisms of the permanently anoxic Cariaco Basin," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Hanna Chen & Lin Zhong & Haibo Zhou & Xianping Bai & Tao Sun & Xingyan Wang & Yiming Zhao & Xiaoqi Ji & Qiang Tu & Youming Zhang & Xiaoying Bian, 2023. "Biosynthesis and engineering of the nonribosomal peptides with a C-terminal putrescine," Nature Communications, Nature, vol. 14(1), pages 1-17, December.

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