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Directing Min protein patterns with advective bulk flow

Author

Listed:
  • Sabrina Meindlhumer

    (Kavli Institute of Nanoscience Delft, Delft University of Technology)

  • Fridtjof Brauns

    (Ludwig-Maximilians-Universität München
    University of California Santa Barbara)

  • Jernej Rudi Finžgar

    (Ludwig-Maximilians-Universität München)

  • Jacob Kerssemakers

    (Kavli Institute of Nanoscience Delft, Delft University of Technology)

  • Cees Dekker

    (Kavli Institute of Nanoscience Delft, Delft University of Technology)

  • Erwin Frey

    (Ludwig-Maximilians-Universität München
    Max Planck School Matter to Life)

Abstract

The Min proteins constitute the best-studied model system for pattern formation in cell biology. We theoretically predict and experimentally show that the propagation direction of in vitro Min protein patterns can be controlled by a hydrodynamic flow of the bulk solution. We find downstream propagation of Min wave patterns for low MinE:MinD concentration ratios, upstream propagation for large ratios, but multistability of both propagation directions in between. Whereas downstream propagation can be described by a minimal model that disregards MinE conformational switching, upstream propagation can be reproduced by a reduced switch model, where increased MinD bulk concentrations on the upstream side promote protein attachment. Our study demonstrates that a differential flow, where bulk flow advects protein concentrations in the bulk, but not on the surface, can control surface-pattern propagation. This suggests that flow can be used to probe molecular features and to constrain mathematical models for pattern-forming systems.

Suggested Citation

  • Sabrina Meindlhumer & Fridtjof Brauns & Jernej Rudi Finžgar & Jacob Kerssemakers & Cees Dekker & Erwin Frey, 2023. "Directing Min protein patterns with advective bulk flow," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-35997-0
    DOI: 10.1038/s41467-023-35997-0
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    References listed on IDEAS

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    1. Elisa Godino & Jonás Noguera López & David Foschepoth & Céline Cleij & Anne Doerr & Clara Ferrer Castellà & Christophe Danelon, 2019. "De novo synthesized Min proteins drive oscillatory liposome deformation and regulate FtsA-FtsZ cytoskeletal patterns," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    2. Esteban Hoijman & Davide Rubbini & Julien Colombelli & Berta Alsina, 2015. "Mitotic cell rounding and epithelial thinning regulate lumen growth and shape," Nature Communications, Nature, vol. 6(1), pages 1-13, November.
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