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Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface

Author

Listed:
  • Srinivas Abbina

    (The University of British Columbia
    The University of British Columbia)

  • Lily E. Takeuchi

    (The University of British Columbia
    The University of British Columbia)

  • Parambath Anilkumar

    (The University of British Columbia
    The University of British Columbia)

  • Kai Yu

    (The University of British Columbia
    The University of British Columbia)

  • Jason C. Rogalski

    (The University of British Columbia)

  • Rajesh A. Shenoi

    (Mahatma Gandhi University Campus at Thalappady)

  • Iren Constantinescu

    (The University of British Columbia
    The University of British Columbia)

  • Jayachandran N. Kizhakkedathu

    (The University of British Columbia
    The University of British Columbia
    The University of British Columbia
    The University of British Columbia)

Abstract

Nanomaterials in the blood must mitigate the immune response to have a prolonged vascular residency in vivo. The composition of the protein corona that forms at the nano-biointerface may be directing this, however, the possible correlation of corona composition with blood residency is currently unknown. Here‚ we report a panel of new soft single molecule polymer nanomaterials (SMPNs) with varying circulation times in mice (t1/2β ~ 22 to 65 h) and use proteomics to probe protein corona at the nano-biointerface to elucidate the mechanism of blood residency of nanomaterials. The composition of the protein opsonins on SMPNs is qualitatively and quantitatively dynamic with time in circulation. SMPNs that circulate longer are able to clear some of the initial surface-bound common opsonins, including immunoglobulins, complement, and coagulation proteins. This continuous remodelling of protein opsonins may be an important decisive step in directing elimination or residence of soft nanomaterials in vivo.

Suggested Citation

  • Srinivas Abbina & Lily E. Takeuchi & Parambath Anilkumar & Kai Yu & Jason C. Rogalski & Rajesh A. Shenoi & Iren Constantinescu & Jayachandran N. Kizhakkedathu, 2020. "Blood circulation of soft nanomaterials is governed by dynamic remodeling of protein opsonins at nano-biointerface," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16772-x
    DOI: 10.1038/s41467-020-16772-x
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    Cited by:

    1. Shen Han & Richard Costa Marques & Johanna Simon & Anke Kaltbeitzel & Kaloian Koynov & Katharina Landfester & Volker Mailänder & Ingo Lieberwirth, 2023. "Endosomal sorting results in a selective separation of the protein corona from nanoparticles," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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