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2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases

Author

Listed:
  • Wei Feng

    (Shanghai University
    Chinese Academy of Sciences)

  • Xiuguo Han

    (Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Hui Hu

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
    Jiangsu University Affiliated People’s Hospital)

  • Meiqi Chang

    (Chinese Academy of Sciences)

  • Li Ding

    (Chinese Academy of Sciences)

  • Huijing Xiang

    (Shanghai University)

  • Yu Chen

    (Shanghai University
    Chinese Academy of Sciences)

  • Yuehua Li

    (Shanghai Jiao Tong University Affiliated Sixth People’s Hospital)

Abstract

Reactive oxygen species (ROS) are generated and consumed in living organism for normal metabolism. Paradoxically, the overproduction and/or mismanagement of ROS have been involved in pathogenesis and progression of various human diseases. Here, we reported a two-dimensional (2D) vanadium carbide (V2C) MXene nanoenzyme (MXenzyme) that can mimic up to six naturally-occurring enzymes, including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione peroxidase (GPx), thiol peroxidase (TPx) and haloperoxidase (HPO). Based on these enzyme-mimicking properties, the constructed 2D V2C MXenzyme not only possesses high biocompatibility but also exhibits robust in vitro cytoprotection against oxidative stress. Importantly, 2D V2C MXenzyme rebuilds the redox homeostasis without perturbing the endogenous antioxidant status and relieves ROS-induced damage with benign in vivo therapeutic effects, as demonstrated in both inflammation and neurodegeneration animal models. These findings open an avenue to enable the use of MXenzyme as a remedial nanoplatform to treat ROS-mediated inflammatory and neurodegenerative diseases.

Suggested Citation

  • Wei Feng & Xiuguo Han & Hui Hu & Meiqi Chang & Li Ding & Huijing Xiang & Yu Chen & Yuehua Li, 2021. "2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:12:y:2021:i:1:d:10.1038_s41467-021-22278-x
    DOI: 10.1038/s41467-021-22278-x
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    Cited by:

    1. Biao Huang & Tao Tang & Shi-Hui Chen & Hao Li & Zhi-Jun Sun & Zhi-Lin Zhang & Mingxi Zhang & Ran Cui, 2023. "Near-infrared-IIb emitting single-atom catalyst for imaging-guided therapy of blood-brain barrier breakdown after traumatic brain injury," Nature Communications, Nature, vol. 14(1), pages 1-16, December.

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