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A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China

Author

Listed:
  • Shaofu Qiu

    (The Chinese PLA Center for Disease Control and Prevention)

  • Kangkang Liu

    (The Chinese PLA Center for Disease Control and Prevention)

  • Chaojie Yang

    (The Chinese PLA Center for Disease Control and Prevention)

  • Ying Xiang

    (The Chinese PLA Center for Disease Control and Prevention)

  • Kaiyuan Min

    (Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Kunpeng Zhu

    (The Chinese PLA Center for Disease Control and Prevention)

  • Hongbo Liu

    (The Chinese PLA Center for Disease Control and Prevention)

  • Xinying Du

    (The Chinese PLA Center for Disease Control and Prevention)

  • Mingjuan Yang

    (The Chinese PLA Center for Disease Control and Prevention)

  • Ligui Wang

    (The Chinese PLA Center for Disease Control and Prevention)

  • Yong Sun

    (Anhui Provincial Center for Disease Control and Prevention)

  • Haijian Zhou

    (Chinese Center for Disease Control and Prevention and State Key Laboratory for Infectious Disease Prevention and Control)

  • Muti Mahe

    (Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region)

  • Jiayong Zhao

    (Henan Provincial Center for Disease Control and Prevention)

  • Shijun Li

    (Guizhou Provincial Center for Disease Control and Prevention)

  • Deshan Yu

    (Gansu Provincial Center for Disease Control and Prevention)

  • Jane Hawkey

    (Monash University)

  • Kathryn E. Holt

    (Monash University)

  • Stephen Baker

    (University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus)

  • Juntao Yang

    (Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Xuebin Xu

    (Shanghai Municipal Center for Disease Control and Prevention)

  • Hongbin Song

    (The Chinese PLA Center for Disease Control and Prevention)

Abstract

Antimicrobial resistance of Shigella sonnei has become a global concern. Here, we report a phylogenetic group of S. sonnei with extensive drug resistance, including a combination of multidrug resistance, coresistance to ceftriaxone and azithromycin (cefRaziR), reduced susceptibility to fluoroquinolones, and even colistin resistance (colR). This distinct clone caused six waterborne shigellosis outbreaks in China from 2015 to 2020. We collect 155 outbreak isolates and 152 sporadic isolates. The cefRaziR isolates, including outbreak strains, are mainly distributed in a distinct clade located in global Lineage III. The outbreak strains form a recently derived monophyletic group that may have emerged circa 2010. The cefRaziR and colR phenotypes are attributed to the acquisition of different plasmids, particularly the IncB/O/K/Z plasmid coharboring the blaCTX-M-14, mphA, aac(3)-IId, dfrA17, aadA5, and sul1 genes and the IncI2 plasmid with an mcr-1 gene. Genetic analyses identify 92 accessory genes and 60 single-nucleotide polymorphisms associated with the cefRaziR phenotype. Surveillance of this clone is required to determine its dissemination and threat to global public health.

Suggested Citation

  • Shaofu Qiu & Kangkang Liu & Chaojie Yang & Ying Xiang & Kaiyuan Min & Kunpeng Zhu & Hongbo Liu & Xinying Du & Mingjuan Yang & Ligui Wang & Yong Sun & Haijian Zhou & Muti Mahe & Jiayong Zhao & Shijun L, 2022. "A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35136-1
    DOI: 10.1038/s41467-022-35136-1
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    References listed on IDEAS

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    1. Kate S. Baker & Timothy J. Dallman & Nigel Field & Tristan Childs & Holly Mitchell & Martin Day & François-Xavier Weill & Sophie Lefèvre & Mathieu Tourdjman & Gwenda Hughes & Claire Jenkins & Nicholas, 2018. "Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    2. Zhili Chang & Shuting Lu & Lihong Chen & Qi Jin & Jian Yang, 2012. "Causative Species and Serotypes of Shigellosis in Mainland China: Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-7, December.
    3. Jane Hawkey & Kalani Paranagama & Kate S. Baker & Rebecca J. Bengtsson & François-Xavier Weill & Nicholas R. Thomson & Stephen Baker & Louise Cerdeira & Zamin Iqbal & Martin Hunt & Danielle J. Ingle &, 2021. "Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
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    Cited by:

    1. George E. Stenhouse & Karen H. Keddy & Rebecca J. Bengtsson & Neil Hall & Anthony M. Smith & Juno Thomas & Miren Iturriza-Gómara & Kate S. Baker, 2023. "The genomic epidemiology of shigellosis in South Africa," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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