IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-35136-1.html
   My bibliography  Save this article

A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China

Author

Listed:
  • Shaofu Qiu

    (The Chinese PLA Center for Disease Control and Prevention)

  • Kangkang Liu

    (The Chinese PLA Center for Disease Control and Prevention)

  • Chaojie Yang

    (The Chinese PLA Center for Disease Control and Prevention)

  • Ying Xiang

    (The Chinese PLA Center for Disease Control and Prevention)

  • Kaiyuan Min

    (Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Kunpeng Zhu

    (The Chinese PLA Center for Disease Control and Prevention)

  • Hongbo Liu

    (The Chinese PLA Center for Disease Control and Prevention)

  • Xinying Du

    (The Chinese PLA Center for Disease Control and Prevention)

  • Mingjuan Yang

    (The Chinese PLA Center for Disease Control and Prevention)

  • Ligui Wang

    (The Chinese PLA Center for Disease Control and Prevention)

  • Yong Sun

    (Anhui Provincial Center for Disease Control and Prevention)

  • Haijian Zhou

    (Chinese Center for Disease Control and Prevention and State Key Laboratory for Infectious Disease Prevention and Control)

  • Muti Mahe

    (Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region)

  • Jiayong Zhao

    (Henan Provincial Center for Disease Control and Prevention)

  • Shijun Li

    (Guizhou Provincial Center for Disease Control and Prevention)

  • Deshan Yu

    (Gansu Provincial Center for Disease Control and Prevention)

  • Jane Hawkey

    (Monash University)

  • Kathryn E. Holt

    (Monash University)

  • Stephen Baker

    (University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus)

  • Juntao Yang

    (Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College)

  • Xuebin Xu

    (Shanghai Municipal Center for Disease Control and Prevention)

  • Hongbin Song

    (The Chinese PLA Center for Disease Control and Prevention)

Abstract

Antimicrobial resistance of Shigella sonnei has become a global concern. Here, we report a phylogenetic group of S. sonnei with extensive drug resistance, including a combination of multidrug resistance, coresistance to ceftriaxone and azithromycin (cefRaziR), reduced susceptibility to fluoroquinolones, and even colistin resistance (colR). This distinct clone caused six waterborne shigellosis outbreaks in China from 2015 to 2020. We collect 155 outbreak isolates and 152 sporadic isolates. The cefRaziR isolates, including outbreak strains, are mainly distributed in a distinct clade located in global Lineage III. The outbreak strains form a recently derived monophyletic group that may have emerged circa 2010. The cefRaziR and colR phenotypes are attributed to the acquisition of different plasmids, particularly the IncB/O/K/Z plasmid coharboring the blaCTX-M-14, mphA, aac(3)-IId, dfrA17, aadA5, and sul1 genes and the IncI2 plasmid with an mcr-1 gene. Genetic analyses identify 92 accessory genes and 60 single-nucleotide polymorphisms associated with the cefRaziR phenotype. Surveillance of this clone is required to determine its dissemination and threat to global public health.

Suggested Citation

  • Shaofu Qiu & Kangkang Liu & Chaojie Yang & Ying Xiang & Kaiyuan Min & Kunpeng Zhu & Hongbo Liu & Xinying Du & Mingjuan Yang & Ligui Wang & Yong Sun & Haijian Zhou & Muti Mahe & Jiayong Zhao & Shijun L, 2022. "A Shigella sonnei clone with extensive drug resistance associated with waterborne outbreaks in China," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35136-1
    DOI: 10.1038/s41467-022-35136-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-35136-1
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-35136-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Zhili Chang & Shuting Lu & Lihong Chen & Qi Jin & Jian Yang, 2012. "Causative Species and Serotypes of Shigellosis in Mainland China: Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-7, December.
    2. Kate S. Baker & Timothy J. Dallman & Nigel Field & Tristan Childs & Holly Mitchell & Martin Day & François-Xavier Weill & Sophie Lefèvre & Mathieu Tourdjman & Gwenda Hughes & Claire Jenkins & Nicholas, 2018. "Horizontal antimicrobial resistance transfer drives epidemics of multiple Shigella species," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    3. Jane Hawkey & Kalani Paranagama & Kate S. Baker & Rebecca J. Bengtsson & François-Xavier Weill & Nicholas R. Thomson & Stephen Baker & Louise Cerdeira & Zamin Iqbal & Martin Hunt & Danielle J. Ingle &, 2021. "Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. George E. Stenhouse & Karen H. Keddy & Rebecca J. Bengtsson & Neil Hall & Anthony M. Smith & Juno Thomas & Miren Iturriza-Gómara & Kate S. Baker, 2023. "The genomic epidemiology of shigellosis in South Africa," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. George E. Stenhouse & Karen H. Keddy & Rebecca J. Bengtsson & Neil Hall & Anthony M. Smith & Juno Thomas & Miren Iturriza-Gómara & Kate S. Baker, 2023. "The genomic epidemiology of shigellosis in South Africa," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Lewis C. E. Mason & David R. Greig & Lauren A. Cowley & Sally R. Partridge & Elena Martinez & Grace A. Blackwell & Charlotte E. Chong & P. Malaka Silva & Rebecca J. Bengtsson & Jenny L. Draper & Andre, 2023. "The evolution and international spread of extensively drug resistant Shigella sonnei," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Sophie Lefèvre & Elisabeth Njamkepo & Sarah Feldman & Corinne Ruckly & Isabelle Carle & Monique Lejay-Collin & Laëtitia Fabre & Iman Yassine & Lise Frézal & Maria Pardos de la Gandara & Arnaud Fontane, 2023. "Rapid emergence of extensively drug-resistant Shigella sonnei in France," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    4. Iman Yassine & Sophie Lefèvre & Elisabeth E. Hansen & Corinne Ruckly & Isabelle Carle & Monique Lejay-Collin & Laëtitia Fabre & Rayane Rafei & Dominique Clermont & Maria Pardos Gandara & Fouad Dabbous, 2022. "Population structure analysis and laboratory monitoring of Shigella by core-genome multilocus sequence typing," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Han Zhang & Yali Si & Xiaofeng Wang & Peng Gong, 2016. "Patterns of Bacillary Dysentery in China, 2005–2010," IJERPH, MDPI, vol. 13(2), pages 1-18, January.
    6. Vincenzo Torraca & Myrsini Kaforou & Jayne Watson & Gina M Duggan & Hazel Guerrero-Gutierrez & Sina Krokowski & Michael Hollinshead & Thomas B Clarke & Rafal J Mostowy & Gillian S Tomlinson & Vanessa , 2019. "Shigella sonnei infection of zebrafish reveals that O-antigen mediates neutrophil tolerance and dysentery incidence," PLOS Pathogens, Public Library of Science, vol. 15(12), pages 1-26, December.
    7. Ying Xiang & Kunpeng Zhu & Kaiyuan Min & Yaowen Zhang & Jiangfeng Liu & Kangkang Liu & Yiran Han & Xinge Li & Xinying Du & Xin Wang & Ying Huang & Xinping Li & Yuqian Peng & Chaojie Yang & Hongbo Liu , 2024. "Characterization of a Salmonella enterica serovar Typhimurium lineage with rough colony morphology and multidrug resistance," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35136-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.