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Genomic perspective on the bacillus causing paratyphoid B fever

Author

Listed:
  • Jane Hawkey

    (Monash University)

  • Lise Frézal

    (Université Paris Cité, Unité des Bactéries pathogènes entériques)

  • Alicia Tran Dien

    (Université Paris Cité, Unité des Bactéries pathogènes entériques
    Gustave Roussy)

  • Anna Zhukova

    (Université Paris Cité, Bioinformatics and Biostatistics Hub)

  • Derek Brown

    (Scottish Microbiology Reference Laboratories (SMiRL))

  • Marie Anne Chattaway

    (United Kingdom Health Security Agency)

  • Sandra Simon

    (Robert Koch-Institute)

  • Hidemasa Izumiya

    (National Institute of Infectious Diseases)

  • Patricia I. Fields

    (Centers for Disease Control and Prevention)

  • Niall De Lappe

    (Galway University Hospitals)

  • Lidia Kaftyreva

    (Pasteur Institute of St Petersburg)

  • Xuebin Xu

    (Shanghai Municipal Centre for Disease Control and Prevention)

  • Junko Isobe

    (Toyama Institute of Health)

  • Dominique Clermont

    (Université Paris Cité, Collection of Institut Pasteur (CIP))

  • Elisabeth Njamkepo

    (Université Paris Cité, Unité des Bactéries pathogènes entériques)

  • Yukihiro Akeda

    (National Institute of Infectious Diseases)

  • Sylvie Issenhuth-Jeanjean

    (Université Paris Cité, Unité des Bactéries pathogènes entériques)

  • Mariia Makarova

    (Pasteur Institute of St Petersburg)

  • Yanan Wang

    (Henan Agricultural University
    Chinese Academy of Sciences (CAS))

  • Martin Hunt

    (European Bioinformatics Institute
    University of Oxford
    John Radcliffe Hospital
    University of Oxford)

  • Brent M. Jenkins

    (Centers for Disease Control and Prevention)

  • Magali Ravel

    (Université Paris Cité, Unité des Bactéries pathogènes entériques)

  • Véronique Guibert

    (Université Paris Cité, Unité des Bactéries pathogènes entériques)

  • Estelle Serre

    (Université Paris Cité, Unité des Bactéries pathogènes entériques)

  • Zoya Matveeva

    (Pasteur Institute of St Petersburg)

  • Laëtitia Fabre

    (Université Paris Cité, Unité des Bactéries pathogènes entériques)

  • Martin Cormican

    (Galway University Hospitals
    University of Galway)

  • Min Yue

    (Zhejiang University College of Animal Sciences
    University of Chinese Academy of Sciences)

  • Baoli Zhu

    (Chinese Academy of Sciences (CAS))

  • Masatomo Morita

    (National Institute of Infectious Diseases)

  • Zamin Iqbal

    (European Bioinformatics Institute
    University of Bath)

  • Carolina Silva Nodari

    (Université Paris Cité, Unité des Bactéries pathogènes entériques)

  • Maria Pardos de la Gandara

    (Université Paris Cité, Unité des Bactéries pathogènes entériques)

  • François-Xavier Weill

    (Université Paris Cité, Unité des Bactéries pathogènes entériques)

Abstract

Paratyphoid B fever (PTB) is caused by an invasive lineage (phylogroup 1, PG1) of Salmonella enterica serotype Paratyphi B (SPB). However, little was known about the global population structure, geographic distribution, and evolution of this pathogen. Here, we report a whole-genome analysis of 568 historical and contemporary SPB PG1 isolates, obtained globally, between 1898 and 2021. We show that this pathogen existed in the 13th century, subsequently diversifying into 11 lineages and 38 genotypes with strong phylogeographic patterns. Following its discovery in 1896, it circulated across Europe until the 1970s, after which it was mostly reimported into Europe from South America, the Middle East, South Asia, and North Africa. Antimicrobial resistance recently emerged in various genotypes of SPB PG1, mostly through mutations of the quinolone-resistance-determining regions of gyrA and gyrB. This study provides an unprecedented insight into SPB PG1 and essential genomic tools for identifying and tracking this pathogen, thereby facilitating the global genomic surveillance of PTB.

Suggested Citation

  • Jane Hawkey & Lise Frézal & Alicia Tran Dien & Anna Zhukova & Derek Brown & Marie Anne Chattaway & Sandra Simon & Hidemasa Izumiya & Patricia I. Fields & Niall De Lappe & Lidia Kaftyreva & Xuebin Xu &, 2024. "Genomic perspective on the bacillus causing paratyphoid B fever," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-54418-4
    DOI: 10.1038/s41467-024-54418-4
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    References listed on IDEAS

    as
    1. Jane Hawkey & Kalani Paranagama & Kate S. Baker & Rebecca J. Bengtsson & François-Xavier Weill & Nicholas R. Thomson & Stephen Baker & Louise Cerdeira & Zamin Iqbal & Martin Hunt & Danielle J. Ingle &, 2021. "Global population structure and genotyping framework for genomic surveillance of the major dysentery pathogen, Shigella sonnei," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    2. Arif M. Tanmoy & Yogesh Hooda & Mohammad S. I. Sajib & Kesia E. Silva & Junaid Iqbal & Farah N. Qamar & Stephen P. Luby & Gordon Dougan & Zoe A. Dyson & Stephen Baker & Denise O. Garrett & Jason R. An, 2022. "Paratype: a genotyping tool for Salmonella Paratyphi A reveals its global genomic diversity," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Vanessa K. Wong & Stephen Baker & Thomas R. Connor & Derek Pickard & Andrew J. Page & Jayshree Dave & Niamh Murphy & Richard Holliman & Armine Sefton & Michael Millar & Zoe A. Dyson & Gordon Dougan & , 2016. "An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid," Nature Communications, Nature, vol. 7(1), pages 1-11, November.
    Full references (including those not matched with items on IDEAS)

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