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Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids

Author

Listed:
  • Qilong Wang

    (Louisville Veterans Administration Medical Center
    James Brown Cancer Center, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, Kentucky 40202, USA)

  • Xiaoying Zhuang

    (James Brown Cancer Center, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, Kentucky 40202, USA)

  • Jingyao Mu

    (James Brown Cancer Center, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, Kentucky 40202, USA)

  • Zhong-Bin Deng

    (University of Louisville)

  • Hong Jiang

    (Louisville Veterans Administration Medical Center
    James Brown Cancer Center, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, Kentucky 40202, USA)

  • Lifeng Zhang

    (James Brown Cancer Center, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, Kentucky 40202, USA)

  • Xiaoyu Xiang

    (James Brown Cancer Center, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, Kentucky 40202, USA)

  • Baomei Wang

    (James Brown Cancer Center, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, Kentucky 40202, USA)

  • Jun Yan

    (University of Louisville)

  • Donald Miller

    (University of Louisville)

  • Huang-Ge Zhang

    (Louisville Veterans Administration Medical Center
    James Brown Cancer Center, University of Louisville, CTRB 309, 505 Hancock Street, Louisville, Kentucky 40202, USA)

Abstract

Although the use of nanotechnology for the delivery of a wide range of medical treatments has potential to reduce adverse effects associated with drug therapy, tissue-specific delivery remains challenging. Here we show that nanoparticles made of grapefruit-derived lipids, which we call grapefruit-derived nanovectors, can deliver chemotherapeutic agents, short interfering RNA, DNA expression vectors and proteins to different types of cells. We demonstrate the in vivo targeting specificity of grapefruit-derived nanovectors by co-delivering therapeutic agents with folic acid, which in turn leads to significantly increasing targeting efficiency to cells expressing folate receptors. The therapeutic potential of grapefruit-derived nanovectors was further demonstrated by enhancing the chemotherapeutic inhibition of tumour growth in two tumour animal models. Grapefruit-derived nanovectors are less toxic than nanoparticles made of synthetic lipids and, when injected intravenously into pregnant mice, do not pass the placental barrier, suggesting that they may be a useful tool for drug delivery.

Suggested Citation

  • Qilong Wang & Xiaoying Zhuang & Jingyao Mu & Zhong-Bin Deng & Hong Jiang & Lifeng Zhang & Xiaoyu Xiang & Baomei Wang & Jun Yan & Donald Miller & Huang-Ge Zhang, 2013. "Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids," Nature Communications, Nature, vol. 4(1), pages 1-13, October.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2886
    DOI: 10.1038/ncomms2886
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    Cited by:

    1. Zhuangzhuang Qiao & Kai Zhang & Jin Liu & Daojian Cheng & Bingran Yu & Nana Zhao & Fu-Jian Xu, 2022. "Biomimetic electrodynamic nanoparticles comprising ginger-derived extracellular vesicles for synergistic anti-infective therapy," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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