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Genetic analysis of seed traits in Sorghum bicolor that affect the human gut microbiome

Author

Listed:
  • Qinnan Yang

    (University of Nebraska
    University of Nebraska)

  • Mallory Haute

    (University of Nebraska
    University of Nebraska)

  • Nate Korth

    (University of Nebraska
    University of Nebraska)

  • Scott E. Sattler

    (Wheat, Sorghum and Forage Research Unit, USDA-ARS
    University of Nebraska)

  • John Toy

    (Wheat, Sorghum and Forage Research Unit, USDA-ARS
    University of Nebraska)

  • Devin J. Rose

    (University of Nebraska
    University of Nebraska
    University of Nebraska)

  • James C. Schnable

    (University of Nebraska
    University of Nebraska
    University of Nebraska)

  • Andrew K. Benson

    (University of Nebraska
    University of Nebraska)

Abstract

Prebiotic fibers, polyphenols and other molecular components of food crops significantly affect the composition and function of the human gut microbiome and human health. The abundance of these, frequently uncharacterized, microbiome-active components vary within individual crop species. Here, we employ high throughput in vitro fermentations of pre-digested grain using a human microbiome to identify segregating genetic loci in a food crop, sorghum, that alter the composition and function of human gut microbes. Evaluating grain produced by 294 sorghum recombinant inbreds identifies 10 loci in the sorghum genome associated with variation in the abundance of microbial taxa and/or microbial metabolites. Two loci co-localize with sorghum genes regulating the biosynthesis of condensed tannins. We validate that condensed tannins stimulate the growth of microbes associated with these two loci. Our work illustrates the potential for genetic analysis to systematically discover and characterize molecular components of food crops that influence the human gut microbiome.

Suggested Citation

  • Qinnan Yang & Mallory Haute & Nate Korth & Scott E. Sattler & John Toy & Devin J. Rose & James C. Schnable & Andrew K. Benson, 2022. "Genetic analysis of seed traits in Sorghum bicolor that affect the human gut microbiome," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33419-1
    DOI: 10.1038/s41467-022-33419-1
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    References listed on IDEAS

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    1. Emma S. Mace & Shuaishuai Tai & Edward K. Gilding & Yanhong Li & Peter J. Prentis & Lianle Bian & Bradley C. Campbell & Wushu Hu & David J. Innes & Xuelian Han & Alan Cruickshank & Changming Dai & Cél, 2013. "Whole-genome sequencing reveals untapped genetic potential in Africa’s indigenous cereal crop sorghum," Nature Communications, Nature, vol. 4(1), pages 1-9, October.
    2. Daphna Rothschild & Omer Weissbrod & Elad Barkan & Alexander Kurilshikov & Tal Korem & David Zeevi & Paul I. Costea & Anastasia Godneva & Iris N. Kalka & Noam Bar & Smadar Shilo & Dar Lador & Arnau Vi, 2018. "Environment dominates over host genetics in shaping human gut microbiota," Nature, Nature, vol. 555(7695), pages 210-215, March.
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