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Small molecule-assisted assembly of multifunctional ceria nanozymes for synergistic treatment of atherosclerosis

Author

Listed:
  • Xiaoxue Fu

    (Chongqing Medical University)

  • Xiaojuan Yu

    (Chongqing Medical University)

  • Junhao Jiang

    (Chongqing Medical University)

  • Jiaxin Yang

    (Chongqing Medical University)

  • Lu Chen

    (Chongqing Medical University)

  • Zhangyou Yang

    (Chongqing Medical University)

  • Chao Yu

    (Chongqing Medical University)

Abstract

Considering that intravascular reactive oxygen species (ROS) and inflammation are two characteristic features of the atherosclerotic microenvironment, developing an appropriate strategy to treat atherosclerosis by synergistically regulating ROS and inflammation has attracted widespread attention. Herein, a special molecule, zoledronic acid, containing imidazole and bisphosphonate groups, was selected for the first time to assist the assembly of cerium ions and produce functionalized ceria-zoledronic acid nanocomposites (CZ NCs). It not only serves as a new carrier for different kinds of drugs (e.g. probucol, PB) but also exerts an efficient multienzyme activity to achieve collaborative therapy. More importantly, platelet membrane-coated biomimetic nanoplatform (PCZ@PB NCs) specifically accumulate at inflammatory atherosclerotic lesions, synergistically regulate ROS levels and inflammation, and efficiently inhibit foam cell formation. This novel assembly method can also be applied in the treatment of many other diseases associated with oxidative stress and inflammation.

Suggested Citation

  • Xiaoxue Fu & Xiaojuan Yu & Junhao Jiang & Jiaxin Yang & Lu Chen & Zhangyou Yang & Chao Yu, 2022. "Small molecule-assisted assembly of multifunctional ceria nanozymes for synergistic treatment of atherosclerosis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34248-y
    DOI: 10.1038/s41467-022-34248-y
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    References listed on IDEAS

    as
    1. Cheng Gao & Qiaoxian Huang & Conghui Liu & Cheryl H. T. Kwong & Ludan Yue & Jian-Bo Wan & Simon M. Y. Lee & Ruibing Wang, 2020. "Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    2. Che-Ming J. Hu & Ronnie H. Fang & Kuei-Chun Wang & Brian T. Luk & Soracha Thamphiwatana & Diana Dehaini & Phu Nguyen & Pavimol Angsantikul & Cindy H. Wen & Ashley V. Kroll & Cody Carpenter & Manikanta, 2015. "Nanoparticle biointerfacing by platelet membrane cloaking," Nature, Nature, vol. 526(7571), pages 118-121, October.
    3. Peter Libby, 2021. "The changing landscape of atherosclerosis," Nature, Nature, vol. 592(7855), pages 524-533, April.
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