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Nanoparticle biointerfacing by platelet membrane cloaking

Author

Listed:
  • Che-Ming J. Hu

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Ronnie H. Fang

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Kuei-Chun Wang

    (University of California, San Diego
    Institute of Engineering in Medicine, University of California, San Diego)

  • Brian T. Luk

    (Moores Cancer Center, University of California, San Diego
    University of California, San Diego)

  • Soracha Thamphiwatana

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Diana Dehaini

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Phu Nguyen

    (University of California, San Diego
    Institute of Engineering in Medicine, University of California, San Diego)

  • Pavimol Angsantikul

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Cindy H. Wen

    (Shiley Eye Institute, University of California, San Diego)

  • Ashley V. Kroll

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Cody Carpenter

    (University of California, San Diego)

  • Manikantan Ramesh

    (University of California, San Diego)

  • Vivian Qu

    (University of California, San Diego)

  • Sherrina H. Patel

    (Shiley Eye Institute, University of California, San Diego)

  • Jie Zhu

    (Shiley Eye Institute, University of California, San Diego)

  • William Shi

    (Shiley Eye Institute, University of California, San Diego)

  • Florence M. Hofman

    (Keck School of Medicine, University of Southern California)

  • Thomas C. Chen

    (Keck School of Medicine, University of Southern California)

  • Weiwei Gao

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Kang Zhang

    (University of California, San Diego
    Institute of Engineering in Medicine, University of California, San Diego
    Shiley Eye Institute, University of California, San Diego
    Veterans Administration Healthcare System)

  • Shu Chien

    (University of California, San Diego
    Institute of Engineering in Medicine, University of California, San Diego)

  • Liangfang Zhang

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego
    Institute of Engineering in Medicine, University of California, San Diego)

Abstract

The authors report a new biomimetic nanodelivery platform in which polymeric nanoparticles enclosed in the plasma membrane of human platelets are used for disease-relevant targeting, and the therapeutic potential of the concept is demonstrated in animal models of coronary restenosis and systemic bacterial infection.

Suggested Citation

  • Che-Ming J. Hu & Ronnie H. Fang & Kuei-Chun Wang & Brian T. Luk & Soracha Thamphiwatana & Diana Dehaini & Phu Nguyen & Pavimol Angsantikul & Cindy H. Wen & Ashley V. Kroll & Cody Carpenter & Manikanta, 2015. "Nanoparticle biointerfacing by platelet membrane cloaking," Nature, Nature, vol. 526(7571), pages 118-121, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7571:d:10.1038_nature15373
    DOI: 10.1038/nature15373
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    Citations

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    Cited by:

    1. Junbin Gao & Hanfeng Qin & Fei Wang & Lu Liu & Hao Tian & Hong Wang & Shuanghu Wang & Juanfeng Ou & Yicheng Ye & Fei Peng & Yingfeng Tu, 2023. "Hyperthermia-triggered biomimetic bubble nanomachines," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Yan Zou & Yajing Sun & Yibin Wang & Dongya Zhang & Huiqing Yang & Xin Wang & Meng Zheng & Bingyang Shi, 2023. "Cancer cell-mitochondria hybrid membrane coated Gboxin loaded nanomedicines for glioblastoma treatment," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Dongdong Wang & Jiawei Liu & Changlai Wang & Weiyun Zhang & Guangbao Yang & Yun Chen & Xiaodong Zhang & Yinglong Wu & Long Gu & Hongzhong Chen & Wei Yuan & Xiaokai Chen & Guofeng Liu & Bin Gao & Qianw, 2023. "Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Xiaoxue Fu & Xiaojuan Yu & Junhao Jiang & Jiaxin Yang & Lu Chen & Zhangyou Yang & Chao Yu, 2022. "Small molecule-assisted assembly of multifunctional ceria nanozymes for synergistic treatment of atherosclerosis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Kaiyuan Wang & Xuanbo Zhang & Hao Ye & Xia Wang & Zhijin Fan & Qi Lu & Songhao Li & Jian Zhao & Shunzhe Zheng & Zhonggui He & Qianqian Ni & Xiaoyuan Chen & Jin Sun, 2023. "Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    6. Yuxin Guo & Shao-Zhe Wang & Xinping Zhang & Hao-Ran Jia & Ya-Xuan Zhu & Xiaodong Zhang & Ge Gao & Yao-Wen Jiang & Chengcheng Li & Xiaokai Chen & Shun-Yu Wu & Yi Liu & Fu-Gen Wu, 2022. "In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    7. Zhaoting Li & Yingyue Ding & Jun Liu & Jianxin Wang & Fanyi Mo & Yixin Wang & Ting-Jing Chen-Mayfield & Paul M. Sondel & Seungpyo Hong & Quanyin Hu, 2022. "Depletion of tumor associated macrophages enhances local and systemic platelet-mediated anti-PD-1 delivery for post-surgery tumor recurrence treatment," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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