IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v526y2015i7571d10.1038_nature15373.html
   My bibliography  Save this article

Nanoparticle biointerfacing by platelet membrane cloaking

Author

Listed:
  • Che-Ming J. Hu

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Ronnie H. Fang

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Kuei-Chun Wang

    (University of California, San Diego
    Institute of Engineering in Medicine, University of California, San Diego)

  • Brian T. Luk

    (Moores Cancer Center, University of California, San Diego
    University of California, San Diego)

  • Soracha Thamphiwatana

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Diana Dehaini

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Phu Nguyen

    (University of California, San Diego
    Institute of Engineering in Medicine, University of California, San Diego)

  • Pavimol Angsantikul

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Cindy H. Wen

    (Shiley Eye Institute, University of California, San Diego)

  • Ashley V. Kroll

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Cody Carpenter

    (University of California, San Diego)

  • Manikantan Ramesh

    (University of California, San Diego)

  • Vivian Qu

    (University of California, San Diego)

  • Sherrina H. Patel

    (Shiley Eye Institute, University of California, San Diego)

  • Jie Zhu

    (Shiley Eye Institute, University of California, San Diego)

  • William Shi

    (Shiley Eye Institute, University of California, San Diego)

  • Florence M. Hofman

    (Keck School of Medicine, University of Southern California)

  • Thomas C. Chen

    (Keck School of Medicine, University of Southern California)

  • Weiwei Gao

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego)

  • Kang Zhang

    (University of California, San Diego
    Institute of Engineering in Medicine, University of California, San Diego
    Shiley Eye Institute, University of California, San Diego
    Veterans Administration Healthcare System)

  • Shu Chien

    (University of California, San Diego
    Institute of Engineering in Medicine, University of California, San Diego)

  • Liangfang Zhang

    (University of California, San Diego
    Moores Cancer Center, University of California, San Diego
    Institute of Engineering in Medicine, University of California, San Diego)

Abstract

The authors report a new biomimetic nanodelivery platform in which polymeric nanoparticles enclosed in the plasma membrane of human platelets are used for disease-relevant targeting, and the therapeutic potential of the concept is demonstrated in animal models of coronary restenosis and systemic bacterial infection.

Suggested Citation

  • Che-Ming J. Hu & Ronnie H. Fang & Kuei-Chun Wang & Brian T. Luk & Soracha Thamphiwatana & Diana Dehaini & Phu Nguyen & Pavimol Angsantikul & Cindy H. Wen & Ashley V. Kroll & Cody Carpenter & Manikanta, 2015. "Nanoparticle biointerfacing by platelet membrane cloaking," Nature, Nature, vol. 526(7571), pages 118-121, October.
    • Handle: RePEc:nat:nature:v:526:y:2015:i:7571:d:10.1038_nature15373
    DOI: 10.1038/nature15373
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature15373
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.
    File URL: https://libkey.io/10.1038/nature15373?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Junbin Gao & Hanfeng Qin & Fei Wang & Lu Liu & Hao Tian & Hong Wang & Shuanghu Wang & Juanfeng Ou & Yicheng Ye & Fei Peng & Yingfeng Tu, 2023. "Hyperthermia-triggered biomimetic bubble nanomachines," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Yan Zou & Yajing Sun & Yibin Wang & Dongya Zhang & Huiqing Yang & Xin Wang & Meng Zheng & Bingyang Shi, 2023. "Cancer cell-mitochondria hybrid membrane coated Gboxin loaded nanomedicines for glioblastoma treatment," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Dongdong Wang & Jiawei Liu & Changlai Wang & Weiyun Zhang & Guangbao Yang & Yun Chen & Xiaodong Zhang & Yinglong Wu & Long Gu & Hongzhong Chen & Wei Yuan & Xiaokai Chen & Guofeng Liu & Bin Gao & Qianw, 2023. "Microbial synthesis of Prussian blue for potentiating checkpoint blockade immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Xiaoxue Fu & Xiaojuan Yu & Junhao Jiang & Jiaxin Yang & Lu Chen & Zhangyou Yang & Chao Yu, 2022. "Small molecule-assisted assembly of multifunctional ceria nanozymes for synergistic treatment of atherosclerosis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    5. Yuxin Guo & Shao-Zhe Wang & Xinping Zhang & Hao-Ran Jia & Ya-Xuan Zhu & Xiaodong Zhang & Ge Gao & Yao-Wen Jiang & Chengcheng Li & Xiaokai Chen & Shun-Yu Wu & Yi Liu & Fu-Gen Wu, 2022. "In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    6. Kaiyuan Wang & Xuanbo Zhang & Hao Ye & Xia Wang & Zhijin Fan & Qi Lu & Songhao Li & Jian Zhao & Shunzhe Zheng & Zhonggui He & Qianqian Ni & Xiaoyuan Chen & Jin Sun, 2023. "Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    7. Zhaoting Li & Yingyue Ding & Jun Liu & Jianxin Wang & Fanyi Mo & Yixin Wang & Ting-Jing Chen-Mayfield & Paul M. Sondel & Seungpyo Hong & Quanyin Hu, 2022. "Depletion of tumor associated macrophages enhances local and systemic platelet-mediated anti-PD-1 delivery for post-surgery tumor recurrence treatment," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:526:y:2015:i:7571:d:10.1038_nature15373. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.