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Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines

Author

Listed:
  • Cheng Gao

    (University of Macau)

  • Qiaoxian Huang

    (University of Macau)

  • Conghui Liu

    (University of Macau)

  • Cheryl H. T. Kwong

    (University of Macau)

  • Ludan Yue

    (University of Macau)

  • Jian-Bo Wan

    (University of Macau)

  • Simon M. Y. Lee

    (University of Macau)

  • Ruibing Wang

    (University of Macau)

Abstract

Vascular disease remains the leading cause of death and disability, the etiology of which often involves atherosclerosis. The current treatment of atherosclerosis by pharmacotherapy has limited therapeutic efficacy. Here we report a biomimetic drug delivery system derived from macrophage membrane coated ROS-responsive nanoparticles (NPs). The macrophage membrane not only avoids the clearance of NPs from the reticuloendothelial system, but also leads NPs to the inflammatory tissues, where the ROS-responsiveness of NPs enables specific payload release. Moreover, the macrophage membrane sequesters proinflammatory cytokines to suppress local inflammation. The synergistic effects of pharmacotherapy and inflammatory cytokines sequestration from such a biomimetic drug delivery system lead to improved therapeutic efficacy in atherosclerosis. Comparison to macrophage internalized with ROS-responsive NPs, as a live-cell based drug delivery system for treatment of atherosclerosis, suggests that cell membrane coated drug delivery approach is likely more suitable for dealing with an inflammatory disease than the live-cell approach.

Suggested Citation

  • Cheng Gao & Qiaoxian Huang & Conghui Liu & Cheryl H. T. Kwong & Ludan Yue & Jian-Bo Wan & Simon M. Y. Lee & Ruibing Wang, 2020. "Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16439-7
    DOI: 10.1038/s41467-020-16439-7
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    Cited by:

    1. M. C. Martinez-Campanario & Marlies Cortés & Alazne Moreno-Lanceta & Lu Han & Chiara Ninfali & Verónica Domínguez & María J. Andrés-Manzano & Marta Farràs & Anna Esteve-Codina & Carlos Enrich & Franci, 2023. "Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    2. Yan Zou & Yajing Sun & Yibin Wang & Dongya Zhang & Huiqing Yang & Xin Wang & Meng Zheng & Bingyang Shi, 2023. "Cancer cell-mitochondria hybrid membrane coated Gboxin loaded nanomedicines for glioblastoma treatment," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Xiaoxue Fu & Xiaojuan Yu & Junhao Jiang & Jiaxin Yang & Lu Chen & Zhangyou Yang & Chao Yu, 2022. "Small molecule-assisted assembly of multifunctional ceria nanozymes for synergistic treatment of atherosclerosis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Cheng Gao & Qingfu Wang & Yuanfu Ding & Cheryl H. T. Kwong & Jinwei Liu & Beibei Xie & Jianwen Wei & Simon M. Y. Lee & Greta S. P. Mok & Ruibing Wang, 2024. "Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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