IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-023-44662-5.html
   My bibliography  Save this article

Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats

Author

Listed:
  • Cheng Gao

    (University of Macau
    University of Macau)

  • Qingfu Wang

    (University of Macau)

  • Yuanfu Ding

    (University of Macau
    University of Macau)

  • Cheryl H. T. Kwong

    (University of Macau)

  • Jinwei Liu

    (University of Macau)

  • Beibei Xie

    (University of Macau)

  • Jianwen Wei

    (University of Macau)

  • Simon M. Y. Lee

    (University of Macau
    University of Macau)

  • Greta S. P. Mok

    (University of Macau
    University of Macau)

  • Ruibing Wang

    (University of Macau
    University of Macau)

Abstract

Membrane-camouflaged nanomedicines often suffer from reduced efficacy caused by membrane protein disintegration and spatial disorder caused by separation and reassembly of membrane fragments during the coating process. Here we show that intracellularly gelated macrophages (GMs) preserve cell membrane structures, including protein content, integration and fluidity, as well as the membrane lipid order. Consequently, in our testing GMs act as cellular sponges to efficiently neutralize various inflammatory cytokines via receptor-ligand interactions, and serve as immune cell-like carriers to selectively bind inflammatory cells in culture medium, even under a flow condition. In a rat model of collagen-induced arthritis, GMs alleviate the joint injury, and suppress the overall arthritis severity. Upon intravenous injection, GMs efficiently accumulate in the inflammatory lungs of acute pneumonia mice for anti-inflammatory therapy. Conveniently, GMs are amenable to lyophilization and can be stored at ambient temperatures for at least 1 month without loss of integrity and bio-activity. This intracellular gelation technology provides a universal platform for targeted inflammation neutralization treatment.

Suggested Citation

  • Cheng Gao & Qingfu Wang & Yuanfu Ding & Cheryl H. T. Kwong & Jinwei Liu & Beibei Xie & Jianwen Wei & Simon M. Y. Lee & Greta S. P. Mok & Ruibing Wang, 2024. "Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44662-5
    DOI: 10.1038/s41467-023-44662-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-44662-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-44662-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Cheng Gao & Qiaoxian Huang & Conghui Liu & Cheryl H. T. Kwong & Ludan Yue & Jian-Bo Wan & Simon M. Y. Lee & Ruibing Wang, 2020. "Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    2. Qiangzhe Zhang & Julia Zhou & Jiarong Zhou & Ronnie H. Fang & Weiwei Gao & Liangfang Zhang, 2021. "Lure-and-kill macrophage nanoparticles alleviate the severity of experimental acute pancreatitis," Nature Communications, Nature, vol. 12(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Yan Zou & Yajing Sun & Yibin Wang & Dongya Zhang & Huiqing Yang & Xin Wang & Meng Zheng & Bingyang Shi, 2023. "Cancer cell-mitochondria hybrid membrane coated Gboxin loaded nanomedicines for glioblastoma treatment," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    2. Yuxin Guo & Shao-Zhe Wang & Xinping Zhang & Hao-Ran Jia & Ya-Xuan Zhu & Xiaodong Zhang & Ge Gao & Yao-Wen Jiang & Chengcheng Li & Xiaokai Chen & Shun-Yu Wu & Yi Liu & Fu-Gen Wu, 2022. "In situ generation of micrometer-sized tumor cell-derived vesicles as autologous cancer vaccines for boosting systemic immune responses," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Xiaoxue Fu & Xiaojuan Yu & Junhao Jiang & Jiaxin Yang & Lu Chen & Zhangyou Yang & Chao Yu, 2022. "Small molecule-assisted assembly of multifunctional ceria nanozymes for synergistic treatment of atherosclerosis," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. M. C. Martinez-Campanario & Marlies Cortés & Alazne Moreno-Lanceta & Lu Han & Chiara Ninfali & Verónica Domínguez & María J. Andrés-Manzano & Marta Farràs & Anna Esteve-Codina & Carlos Enrich & Franci, 2023. "Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44662-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.