CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma
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DOI: 10.1038/s41467-022-34179-8
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References listed on IDEAS
- Sara J. Dubbury & Paul L. Boutz & Phillip A. Sharp, 2018. "CDK12 regulates DNA repair genes by suppressing intronic polyadenylation," Nature, Nature, vol. 564(7734), pages 141-145, December.
- Nicholas Kwiatkowski & Tinghu Zhang & Peter B. Rahl & Brian J. Abraham & Jessica Reddy & Scott B. Ficarro & Anahita Dastur & Arnaud Amzallag & Sridhar Ramaswamy & Bethany Tesar & Catherine E. Jenkins , 2014. "Targeting transcription regulation in cancer with a covalent CDK7 inhibitor," Nature, Nature, vol. 511(7511), pages 616-620, July.
- Chong Sun & Liqin Wang & Sidong Huang & Guus J. J. E. Heynen & Anirudh Prahallad & Caroline Robert & John Haanen & Christian Blank & Jelle Wesseling & Stefan M. Willems & Davide Zecchin & Sebastijan H, 2014. "Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma," Nature, Nature, vol. 508(7494), pages 118-122, April.
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