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The potential of Beta variant containing COVID booster vaccines for chasing Omicron in 2022

Author

Listed:
  • Saranya Sridhar

    (Sanofi)

  • Roman M. Chicz

    (Sanofi)

  • William Warren

    (Sanofi
    Sanofi)

  • Jim Tartaglia

    (Sanofi)

  • Stephen Savarino

    (Sanofi)

  • Sanjay Gurunathan

    (Sanofi)

  • Jean-Francois Toussaint

    (Sanofi)

Abstract

Currently approved COVID vaccines are designed using the spike antigen derived from the ancestral strain, but health authorities are recommending changes to the vaccine strain to combat emerging variants. The goal is to ensure that next generation vaccines can tackle multiple variants of concern including the most prevalent variant for the coming season. We here discuss recent preclinical and clinical data on COVID vaccine antigens that are potential candidates for an updated vaccine.

Suggested Citation

  • Saranya Sridhar & Roman M. Chicz & William Warren & Jim Tartaglia & Stephen Savarino & Sanjay Gurunathan & Jean-Francois Toussaint, 2022. "The potential of Beta variant containing COVID booster vaccines for chasing Omicron in 2022," Nature Communications, Nature, vol. 13(1), pages 1-3, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33549-6
    DOI: 10.1038/s41467-022-33549-6
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    References listed on IDEAS

    as
    1. Rahul K. Suryawanshi & Irene P. Chen & Tongcui Ma & Abdullah M. Syed & Noah Brazer & Prachi Saldhi & Camille R. Simoneau & Alison Ciling & Mir M. Khalid & Bharath Sreekumar & Pei-Yi Chen & G. Renuka K, 2022. "Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination," Nature, Nature, vol. 607(7918), pages 351-355, July.
    2. Vincent Pavot & Catherine Berry & Michael Kishko & Natalie G. Anosova & Dean Huang & Tim Tibbitts & Alice Raillard & Sylviane Gautheron & Cindy Gutzeit & Marguerite Koutsoukos & Roman M. Chicz & Valer, 2022. "Protein-based SARS-CoV-2 spike vaccine booster increases cross-neutralization against SARS-CoV-2 variants of concern in non-human primates," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
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    Cited by:

    1. Vincent Pavot & Catherine Berry & Michael Kishko & Natalie G. Anosova & Lu Li & Tim Tibbitts & Dean Huang & Alice Raillard & Sylviane Gautheron & Cindy Gutzeit & Marguerite Koutsoukos & Roman M. Chicz, 2023. "Beta variant COVID-19 protein booster vaccine elicits durable cross-neutralization against SARS-CoV-2 variants in non-human primates," Nature Communications, Nature, vol. 14(1), pages 1-8, December.
    2. Lorena M. Coria & Juan Manuel Rodriguez & Agostina Demaria & Laura A. Bruno & Mayra Rios Medrano & Celeste Pueblas Castro & Eliana F. Castro & Sabrina A. Del Priore & Andres C. Hernando Insua & Ingrid, 2024. "A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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