IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-33262-4.html
   My bibliography  Save this article

Predictive model for cytoneme guidance in Hedgehog signaling based on Ihog- Glypicans interaction

Author

Listed:
  • Adrián Aguirre-Tamaral

    (Universidad Autónoma de Madrid, Cantoblanco
    Universidad de Granada)

  • Manuel Cambón

    (Universidad de Granada)

  • David Poyato

    (Universidad de Granada
    UMR 5208 CNRS & Université Claude Bernard Lyon 1)

  • Juan Soler

    (Universidad de Granada)

  • Isabel Guerrero

    (Universidad Autónoma de Madrid, Cantoblanco)

Abstract

During embryonic development, cell-cell communication is crucial to coordinate cell behavior, especially in the generation of differentiation patterns via morphogen gradients. Morphogens are signaling molecules secreted by a source of cells that elicit concentration-dependent responses in target cells. For several morphogens, cell-cell contact via filopodia-like-structures (cytonemes) has been proposed as a mechanism for their gradient formation. Despite of the advances on cytoneme signaling, little is known about how cytonemes navigate through the extracellular matrix and how they orient to find their target. For the Hedgehog (Hh) signaling pathway in Drosophila, Hh co-receptor and adhesion protein Interference hedgehog (Ihog) and the glypicans Dally and Dally-like-protein (Dlp) interact affecting the cytoneme behavior. Here, we describe that differences in the cytoneme stabilization and orientation depend on the relative levels of Ihog and glypicans, suggesting a mechanism for cytoneme guidance. Furthermore, we have developed a mathematical model to study and corroborate this cytoneme guiding mechanism.

Suggested Citation

  • Adrián Aguirre-Tamaral & Manuel Cambón & David Poyato & Juan Soler & Isabel Guerrero, 2022. "Predictive model for cytoneme guidance in Hedgehog signaling based on Ihog- Glypicans interaction," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33262-4
    DOI: 10.1038/s41467-022-33262-4
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-33262-4
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-33262-4?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Timothy A. Sanders & Esther Llagostera & Maria Barna, 2013. "Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning," Nature, Nature, vol. 497(7451), pages 628-632, May.
    2. Akshay Patel & Yicong Wu & Xiaofei Han & Yijun Su & Tim Maugel & Hari Shroff & Sougata Roy, 2022. "Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Eliana Stanganello & Anja I. H. Hagemann & Benjamin Mattes & Claude Sinner & Dana Meyen & Sabrina Weber & Alexander Schug & Erez Raz & Steffen Scholpp, 2015. "Filopodia-based Wnt transport during vertebrate tissue patterning," Nature Communications, Nature, vol. 6(1), pages 1-14, May.
    4. Ana-Citlali Gradilla & Esperanza González & Irene Seijo & German Andrés & Marcus Bischoff & Laura González-Mendez & Vanessa Sánchez & Ainhoa Callejo & Carmen Ibáñez & Milagros Guerra & João Ramalho Or, 2014. "Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion," Nature Communications, Nature, vol. 5(1), pages 1-13, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Fabian Gude & Jurij Froese & Dominique Manikowski & Daniele Di Iorio & Jean-Noël Grad & Seraphine Wegner & Daniel Hoffmann & Melissa Kennedy & Ralf P. Richter & Georg Steffes & Kay Grobe, 2023. "Hedgehog is relayed through dynamic heparan sulfate interactions to shape its gradient," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Lijuan Du & Alex Sohr & Yujia Li & Sougata Roy, 2022. "GPI-anchored FGF directs cytoneme-mediated bidirectional contacts to regulate its tissue-specific dispersion," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    3. Timo Kuhn & Amit N. Landge & David Mörsdorf & Jonas Coßmann & Johanna Gerstenecker & Daniel Čapek & Patrick Müller & J. Christof M. Gebhardt, 2022. "Single-molecule tracking of Nodal and Lefty in live zebrafish embryos supports hindered diffusion model," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33262-4. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.