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Predictive model for cytoneme guidance in Hedgehog signaling based on Ihog- Glypicans interaction

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  • Adrián Aguirre-Tamaral

    (Universidad Autónoma de Madrid, Cantoblanco
    Universidad de Granada)

  • Manuel Cambón

    (Universidad de Granada)

  • David Poyato

    (Universidad de Granada
    UMR 5208 CNRS & Université Claude Bernard Lyon 1)

  • Juan Soler

    (Universidad de Granada)

  • Isabel Guerrero

    (Universidad Autónoma de Madrid, Cantoblanco)

Abstract

During embryonic development, cell-cell communication is crucial to coordinate cell behavior, especially in the generation of differentiation patterns via morphogen gradients. Morphogens are signaling molecules secreted by a source of cells that elicit concentration-dependent responses in target cells. For several morphogens, cell-cell contact via filopodia-like-structures (cytonemes) has been proposed as a mechanism for their gradient formation. Despite of the advances on cytoneme signaling, little is known about how cytonemes navigate through the extracellular matrix and how they orient to find their target. For the Hedgehog (Hh) signaling pathway in Drosophila, Hh co-receptor and adhesion protein Interference hedgehog (Ihog) and the glypicans Dally and Dally-like-protein (Dlp) interact affecting the cytoneme behavior. Here, we describe that differences in the cytoneme stabilization and orientation depend on the relative levels of Ihog and glypicans, suggesting a mechanism for cytoneme guidance. Furthermore, we have developed a mathematical model to study and corroborate this cytoneme guiding mechanism.

Suggested Citation

  • Adrián Aguirre-Tamaral & Manuel Cambón & David Poyato & Juan Soler & Isabel Guerrero, 2022. "Predictive model for cytoneme guidance in Hedgehog signaling based on Ihog- Glypicans interaction," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33262-4
    DOI: 10.1038/s41467-022-33262-4
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    References listed on IDEAS

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    1. Timothy A. Sanders & Esther Llagostera & Maria Barna, 2013. "Specialized filopodia direct long-range transport of SHH during vertebrate tissue patterning," Nature, Nature, vol. 497(7451), pages 628-632, May.
    2. Akshay Patel & Yicong Wu & Xiaofei Han & Yijun Su & Tim Maugel & Hari Shroff & Sougata Roy, 2022. "Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Ana-Citlali Gradilla & Esperanza González & Irene Seijo & German Andrés & Marcus Bischoff & Laura González-Mendez & Vanessa Sánchez & Ainhoa Callejo & Carmen Ibáñez & Milagros Guerra & João Ramalho Or, 2014. "Exosomes as Hedgehog carriers in cytoneme-mediated transport and secretion," Nature Communications, Nature, vol. 5(1), pages 1-13, December.
    4. Eliana Stanganello & Anja I. H. Hagemann & Benjamin Mattes & Claude Sinner & Dana Meyen & Sabrina Weber & Alexander Schug & Erez Raz & Steffen Scholpp, 2015. "Filopodia-based Wnt transport during vertebrate tissue patterning," Nature Communications, Nature, vol. 6(1), pages 1-14, May.
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