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The development of synaptic transmission is time-locked to early social behaviors in rats

Author

Listed:
  • Shovan Naskar

    (Istituto Italiano di Tecnologia
    Università degli Studi di Genova)

  • Roberto Narducci

    (Istituto Italiano di Tecnologia)

  • Edoardo Balzani

    (Università degli Studi di Genova
    Istituto Italiano di Tecnologia)

  • Andrzej W. Cwetsch

    (Istituto Italiano di Tecnologia
    Università degli Studi di Genova)

  • Valter Tucci

    (Istituto Italiano di Tecnologia)

  • Laura Cancedda

    (Istituto Italiano di Tecnologia
    Dulbecco Telethon Institute)

Abstract

The development of functional synapses is a sequential process preserved across many brain areas. Here, we show that glutamatergic postsynaptic currents anticipated GABAergic currents in Layer II/III of the rat neocortex, in contrast to the pattern described for other brain areas. The frequencies of both glutamatergic and GABAergic currents increased abruptly at the beginning of the second postnatal week, supported by a serotonin upsurge. Integrative behaviors arose on postnatal day (P)9, while most motor and sensory behaviors, which are fundamental for pup survival, were already in place at approximately P7. A reduction in serotonin reuptake accelerated the development of functional synapses and integrative huddling behavior, while sparing motor and sensory function development. A decrease in synaptic transmission in Layer II/III induced by a chemogenetic approach only inhibited huddling. Thus, precise developmental sequences mediate early, socially directed behaviors for which neurotransmission and its modulation in supragranular cortical layers play key roles.

Suggested Citation

  • Shovan Naskar & Roberto Narducci & Edoardo Balzani & Andrzej W. Cwetsch & Valter Tucci & Laura Cancedda, 2019. "The development of synaptic transmission is time-locked to early social behaviors in rats," Nature Communications, Nature, vol. 10(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-09156-3
    DOI: 10.1038/s41467-019-09156-3
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    Cited by:

    1. Hyosang Kim & Doyoun Kim & Yisul Cho & Kyungdeok Kim & Junyeop Daniel Roh & Yangsik Kim & Esther Yang & Seong Soon Kim & Sunjoo Ahn & Hyun Kim & Hyojin Kang & Yongchul Bae & Eunjoon Kim, 2022. "Early postnatal serotonin modulation prevents adult-stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming," Nature Communications, Nature, vol. 13(1), pages 1-19, December.

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