IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-32615-3.html
   My bibliography  Save this article

Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent

Author

Listed:
  • Liang Dong

    (University of Science and Technology of China
    Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
    Hefei University of Technology)

  • Yun-Jun Xu

    (The First Affiliated Hospital of University of Science and Technology of China)

  • Cong Sui

    (University of Science and Technology of China)

  • Yang Zhao

    (University of Science and Technology of China)

  • Li-Bo Mao

    (University of Science and Technology of China)

  • Denis Gebauer

    (Leibniz Universität Hannover)

  • Rose Rosenberg

    (University of Konstanz)

  • Jonathan Avaro

    (Scientist - Center for X-ray Analytics, Empa - Swiss Federal Laboratories for Materials Science and Technology)

  • Ya-Dong Wu

    (Hefei University of Technology)

  • Huai-Ling Gao

    (University of Science and Technology of China)

  • Zhao Pan

    (University of Science and Technology of China
    Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences)

  • Hui-Qin Wen

    (The First Affiliated Hospital of Anhui Medical University)

  • Xu Yan

    (Hefei University of Technology)

  • Fei Li

    (Hefei University of Technology)

  • Yang Lu

    (Hefei University of Technology)

  • Helmut Cölfen

    (University of Konstanz)

  • Shu-Hong Yu

    (University of Science and Technology of China)

Abstract

Amorphous calcium carbonate plays a key role as transient precursor in the early stages of biogenic calcium carbonate formation in nature. However, due to its instability in aqueous solution, there is still rare success to utilize amorphous calcium carbonate in biomedicine. Here, we report the mutual effect between paramagnetic gadolinium ions and amorphous calcium carbonate, resulting in ultrafine paramagnetic amorphous carbonate nanoclusters in the presence of both gadolinium occluded highly hydrated carbonate-like environment and poly(acrylic acid). Gadolinium is confirmed to enhance the water content in amorphous calcium carbonate, and the high water content of amorphous carbonate nanoclusters contributes to the much enhanced magnetic resonance imaging contrast efficiency compared with commercially available gadolinium-based contrast agents. Furthermore, the enhanced T1 weighted magnetic resonance imaging performance and biocompatibility of amorphous carbonate nanoclusters are further evaluated in various animals including rat, rabbit and beagle dog, in combination with promising safety in vivo. Overall, exceptionally facile mass-productive amorphous carbonate nanoclusters exhibit superb imaging performance and impressive stability, which provides a promising strategy to design magnetic resonance contrast agent.

Suggested Citation

  • Liang Dong & Yun-Jun Xu & Cong Sui & Yang Zhao & Li-Bo Mao & Denis Gebauer & Rose Rosenberg & Jonathan Avaro & Ya-Dong Wu & Huai-Ling Gao & Zhao Pan & Hui-Qin Wen & Xu Yan & Fei Li & Yang Lu & Helmut , 2022. "Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32615-3
    DOI: 10.1038/s41467-022-32615-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-32615-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-32615-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Randy P. Carney & Jin Young Kim & Huifeng Qian & Rongchao Jin & Hakim Mehenni & Francesco Stellacci & Osman M. Bakr, 2011. "Determination of nanoparticle size distribution together with density or molecular weight by 2D analytical ultracentrifugation," Nature Communications, Nature, vol. 2(1), pages 1-8, September.
    2. Johannes Ihli & Wai Ching Wong & Elizabeth H. Noel & Yi-Yeoun Kim & Alexander N. Kulak & Hugo K. Christenson & Melinda J. Duer & Fiona C. Meldrum, 2014. "Dehydration and crystallization of amorphous calcium carbonate in solution and in air," Nature Communications, Nature, vol. 5(1), pages 1-10, May.
    3. Yifei Xu & Koen C. H. Tijssen & Paul H. H. Bomans & Anat Akiva & Heiner Friedrich & Arno P. M. Kentgens & Nico A. J. M. Sommerdijk, 2018. "Microscopic structure of the polymer-induced liquid precursor for calcium carbonate," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    4. Zhaoming Liu & Changyu Shao & Biao Jin & Zhisen Zhang & Yueqi Zhao & Xurong Xu & Ruikang Tang, 2019. "Crosslinking ionic oligomers as conformable precursors to calcium carbonate," Nature, Nature, vol. 574(7778), pages 394-398, October.
    5. Yongdong Jin & Congxian Jia & Sheng-Wen Huang & Matthew O'Donnell & Xiaohu Gao, 2010. "Multifunctional nanoparticles as coupled contrast agents," Nature Communications, Nature, vol. 1(1), pages 1-8, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Maxim B. Gindele & Sanjay Vinod-Kumar & Johannes Rochau & Daniel Boemke & Eduard Groß & Venkata SubbaRao Redrouthu & Denis Gebauer & Guinevere Mathies, 2024. "Colloidal pathways of amorphous calcium carbonate formation lead to distinct water environments and conductivity," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    2. Feng Jin & Jie Liu & Yuan-Yuan Zhao & Xian-Zi Dong & Mei-Ling Zheng & Xuan-Ming Duan, 2022. "λ/30 inorganic features achieved by multi-photon 3D lithography," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    3. Zhao, Zhenlu & Wu, Haoxi & Li, Chuanping, 2021. "Engineering iron phosphide-on-plasmonic Ag/Au-nanoshells as an efficient cathode catalyst in water splitting for hydrogen production," Energy, Elsevier, vol. 218(C).
    4. Marcel Rey & Johannes Walter & Johannes Harrer & Carmen Morcillo Perez & Salvatore Chiera & Sharanya Nair & Maret Ickler & Alesa Fuchs & Mark Michaud & Maximilian J. Uttinger & Andrew B. Schofield & J, 2022. "Versatile strategy for homogeneous drying patterns of dispersed particles," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32615-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.