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Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent

Author

Listed:
  • Liang Dong

    (University of Science and Technology of China
    Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences
    Hefei University of Technology)

  • Yun-Jun Xu

    (The First Affiliated Hospital of University of Science and Technology of China)

  • Cong Sui

    (University of Science and Technology of China)

  • Yang Zhao

    (University of Science and Technology of China)

  • Li-Bo Mao

    (University of Science and Technology of China)

  • Denis Gebauer

    (Leibniz Universität Hannover)

  • Rose Rosenberg

    (University of Konstanz)

  • Jonathan Avaro

    (Scientist - Center for X-ray Analytics, Empa - Swiss Federal Laboratories for Materials Science and Technology)

  • Ya-Dong Wu

    (Hefei University of Technology)

  • Huai-Ling Gao

    (University of Science and Technology of China)

  • Zhao Pan

    (University of Science and Technology of China
    Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences)

  • Hui-Qin Wen

    (The First Affiliated Hospital of Anhui Medical University)

  • Xu Yan

    (Hefei University of Technology)

  • Fei Li

    (Hefei University of Technology)

  • Yang Lu

    (Hefei University of Technology)

  • Helmut Cölfen

    (University of Konstanz)

  • Shu-Hong Yu

    (University of Science and Technology of China)

Abstract

Amorphous calcium carbonate plays a key role as transient precursor in the early stages of biogenic calcium carbonate formation in nature. However, due to its instability in aqueous solution, there is still rare success to utilize amorphous calcium carbonate in biomedicine. Here, we report the mutual effect between paramagnetic gadolinium ions and amorphous calcium carbonate, resulting in ultrafine paramagnetic amorphous carbonate nanoclusters in the presence of both gadolinium occluded highly hydrated carbonate-like environment and poly(acrylic acid). Gadolinium is confirmed to enhance the water content in amorphous calcium carbonate, and the high water content of amorphous carbonate nanoclusters contributes to the much enhanced magnetic resonance imaging contrast efficiency compared with commercially available gadolinium-based contrast agents. Furthermore, the enhanced T1 weighted magnetic resonance imaging performance and biocompatibility of amorphous carbonate nanoclusters are further evaluated in various animals including rat, rabbit and beagle dog, in combination with promising safety in vivo. Overall, exceptionally facile mass-productive amorphous carbonate nanoclusters exhibit superb imaging performance and impressive stability, which provides a promising strategy to design magnetic resonance contrast agent.

Suggested Citation

  • Liang Dong & Yun-Jun Xu & Cong Sui & Yang Zhao & Li-Bo Mao & Denis Gebauer & Rose Rosenberg & Jonathan Avaro & Ya-Dong Wu & Huai-Ling Gao & Zhao Pan & Hui-Qin Wen & Xu Yan & Fei Li & Yang Lu & Helmut , 2022. "Highly hydrated paramagnetic amorphous calcium carbonate nanoclusters as an MRI contrast agent," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32615-3
    DOI: 10.1038/s41467-022-32615-3
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    References listed on IDEAS

    as
    1. Zhaoming Liu & Changyu Shao & Biao Jin & Zhisen Zhang & Yueqi Zhao & Xurong Xu & Ruikang Tang, 2019. "Crosslinking ionic oligomers as conformable precursors to calcium carbonate," Nature, Nature, vol. 574(7778), pages 394-398, October.
    2. Randy P. Carney & Jin Young Kim & Huifeng Qian & Rongchao Jin & Hakim Mehenni & Francesco Stellacci & Osman M. Bakr, 2011. "Determination of nanoparticle size distribution together with density or molecular weight by 2D analytical ultracentrifugation," Nature Communications, Nature, vol. 2(1), pages 1-8, September.
    3. Yongdong Jin & Congxian Jia & Sheng-Wen Huang & Matthew O'Donnell & Xiaohu Gao, 2010. "Multifunctional nanoparticles as coupled contrast agents," Nature Communications, Nature, vol. 1(1), pages 1-8, December.
    4. Johannes Ihli & Wai Ching Wong & Elizabeth H. Noel & Yi-Yeoun Kim & Alexander N. Kulak & Hugo K. Christenson & Melinda J. Duer & Fiona C. Meldrum, 2014. "Dehydration and crystallization of amorphous calcium carbonate in solution and in air," Nature Communications, Nature, vol. 5(1), pages 1-10, May.
    5. Yifei Xu & Koen C. H. Tijssen & Paul H. H. Bomans & Anat Akiva & Heiner Friedrich & Arno P. M. Kentgens & Nico A. J. M. Sommerdijk, 2018. "Microscopic structure of the polymer-induced liquid precursor for calcium carbonate," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
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    1. Yuan Chen & Li Zhang & Xingjie Wu & Xuecheng Sun & Noah R. Sundah & Chi Yan Wong & Auginia Natalia & John K. C. Tam & Darren Wan-Teck Lim & Balram Chowbay & Beng Ti Ang & Carol Tang & Tze Ping Loh & H, 2024. "Magnetic augmentation through multi-gradient coupling enables direct and programmable profiling of circulating biomarkers," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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