IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-32349-2.html
   My bibliography  Save this article

Biomimetic material degradation for synergistic enhanced therapy by regulating endogenous energy metabolism imaging under hypothermia

Author

Listed:
  • Kai Cheng

    (Huazhong University of Science and Technology)

  • Bo Liu

    (Huazhong University of Science and Technology)

  • Xiao-Shuai Zhang

    (Huazhong University of Science and Technology)

  • Ruo-Yun Zhang

    (Huazhong University of Science and Technology)

  • Fang Zhang

    (Huazhong University of Science and Technology)

  • Ghazal Ashraf

    (Huazhong University of Science and Technology)

  • Guo-Qing Fan

    (Huazhong University of Science and Technology)

  • Ming-Yu Tian

    (Huazhong University of Science and Technology)

  • Xing Sun

    (Huazhong University of Science and Technology)

  • Jing Yuan

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

  • Yuan-Di Zhao

    (Huazhong University of Science and Technology
    Huazhong University of Science and Technology)

Abstract

Inefficient tumour treatment approaches often cause fatal tumour metastases. Here, we report a biomimetic multifunctional nanoplatform explicitly engineered with a Co-based metal organic framework polydopamine heterostructure (MOF-PDA), anethole trithione (ADT), and a macrophage membrane. Co-MOF degradation in the tumour microenvironment releases Co2+, which results in the downregulation of HSP90 expression and the inhibition of cellular heat resistance, thereby improving the photothermal therapy effect of PDA. H2S secretion after the enzymatic hydrolysis of ADT leads to high-concentration gas therapy. Moreover, ADT changes the balance between nicotinamide adenine dinucleotide/flavin adenine dinucleotide (NADH/FAD) during tumour glycolysis. ATP synthesis is limited by NADH consumption, which triggers a certain degree of tumour growth inhibition and results in starvation therapy. Potentiated 2D/3D autofluorescence imaging of NADH/FAD is also achieved in liquid nitrogen and employed to efficiently monitor tumour therapy. The developed biomimetic nanoplatform provides an approach to treat orthotopic tumours and inhibit metastasis.

Suggested Citation

  • Kai Cheng & Bo Liu & Xiao-Shuai Zhang & Ruo-Yun Zhang & Fang Zhang & Ghazal Ashraf & Guo-Qing Fan & Ming-Yu Tian & Xing Sun & Jing Yuan & Yuan-Di Zhao, 2022. "Biomimetic material degradation for synergistic enhanced therapy by regulating endogenous energy metabolism imaging under hypothermia," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32349-2
    DOI: 10.1038/s41467-022-32349-2
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-32349-2
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-32349-2?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Thomas A. Wynn & Ajay Chawla & Jeffrey W. Pollard, 2013. "Macrophage biology in development, homeostasis and disease," Nature, Nature, vol. 496(7446), pages 445-455, April.
    2. Ru Li & Yujie Huang & Jun Lin, 2020. "Distinct effects of general anesthetics on lung metastasis mediated by IL-6/JAK/STAT3 pathway in mouse models," Nature Communications, Nature, vol. 11(1), pages 1-10, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Heewon Cho & Haw-Young Kwon & Amit Sharma & Sun Hyeok Lee & Xiao Liu & Naoki Miyamoto & Jong-Jin Kim & Sin-Hyeog Im & Nam-Young Kang & Young-Tae Chang, 2022. "Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    2. Xiaowei Gu & Anna Heinrich & Shu-Yun Li & Tony DeFalco, 2023. "Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Ariel C. Vonk & Xiaofan Zhao & Zheyu Pan & Megan L. Hudnall & Conrad G. Oakes & Gabriela A. Lopez & Sarah C. Hasel-Kolossa & Alexander W. C. Kuncz & Sasha B. Sengelmann & Darian J. Gamble & Thomas P. , 2023. "Single-cell analysis of lizard blastema fibroblasts reveals phagocyte-dependent activation of Hedgehog-responsive chondrogenesis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    4. Julian C. Bahr & Xiao-Yan Li & Tamar Y. Feinberg & Long Jiang & Stephen J. Weiss, 2022. "Divergent regulation of basement membrane trafficking by human macrophages and cancer cells," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    5. Fabian Gondorf & Afiat Berbudi & Benedikt C Buerfent & Jesuthas Ajendra & Dominique Bloemker & Sabine Specht & David Schmidt & Anna-Lena Neumann & Laura E Layland & Achim Hoerauf & Marc P Hübner, 2015. "Chronic Filarial Infection Provides Protection against Bacterial Sepsis by Functionally Reprogramming Macrophages," PLOS Pathogens, Public Library of Science, vol. 11(1), pages 1-27, January.
    6. Pravin Kesarwani & Shiva Kant & Yi Zhao & Antony Prabhu & Katie L. Buelow & C. Ryan Miller & Prakash Chinnaiyan, 2023. "Quinolinate promotes macrophage-induced immune tolerance in glioblastoma through the NMDAR/PPARγ signaling axis," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    7. Qizhou Lian & Kui Zhang & Zhao Zhang & Fuyu Duan & Liyan Guo & Weiren Luo & Bobo Wing-Yee Mok & Abhimanyu Thakur & Xiaoshan Ke & Pedram Motallebnejad & Vlad Nicolaescu & Jonathan Chen & Chui Yan Ma & , 2022. "Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    8. Nicolas Denans & Nhung T. T. Tran & Madeleine E. Swall & Daniel C. Diaz & Jillian Blanck & Tatjana Piotrowski, 2022. "An anti-inflammatory activation sequence governs macrophage transcriptional dynamics during tissue injury in zebrafish," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    9. Chandler D. Gatenbee & Ann-Marie Baker & Ryan O. Schenck & Maximilian Strobl & Jeffrey West & Margarida P. Neves & Sara Yakub Hasan & Eszter Lakatos & Pierre Martinez & William C. H. Cross & Marnix Ja, 2022. "Immunosuppressive niche engineering at the onset of human colorectal cancer," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    10. Shiman Zuo & Yuxin Wang & Hanjing Bao & Zehui Zhang & Nanfei Yang & Meng Jia & Qing Zhang & Ani Jian & Rong Ji & Lidan Zhang & Yan Lu & Yahong Huang & Pingping Shen, 2024. "Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    11. Chen Chen & Bongsoo Park & Emeline Ragonnaud & Monica Bodogai & Xin Wang & Le Zong & Jung-Min Lee & Isabel Beerman & Arya Biragyn, 2022. "Cancer co-opts differentiation of B-cell precursors into macrophage-like cells," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    12. Azahara María García-Serna & Elena Martín-Orozco & Trinidad Hernández-Caselles & Eva Morales, 2021. "Prenatal and Perinatal Environmental Influences Shaping the Neonatal Immune System: A Focus on Asthma and Allergy Origins," IJERPH, MDPI, vol. 18(8), pages 1-24, April.
    13. Wenyan Xie & Qinghua Xue & Liangfei Niu & Ka-Wing Wong, 2020. "Zinc transporter SLC39A7 relieves zinc deficiency to suppress alternative macrophage activation and impairment of phagocytosis," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-12, July.
    14. Michelle J Iandiorio & Jeanne M Fair & Stylianos Chatzipanagiotou & Anastasios Ioannidis & Eleftheria Trikka-Graphakos & Nikoletta Charalampaki & Christina Sereti & George P Tegos & Almira L Hoogestei, 2016. "Preventing Data Ambiguity in Infectious Diseases with Four-Dimensional and Personalized Evaluations," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-19, July.
    15. Gesham Magombedze & Shigetoshi Eda & Vitaly V Ganusov, 2014. "Competition for Antigen between Th1 and Th2 Responses Determines the Timing of the Immune Response Switch during Mycobaterium avium Subspecies paratuberulosis Infection in Ruminants," PLOS Computational Biology, Public Library of Science, vol. 10(1), pages 1-13, January.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32349-2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.