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The importance of antimicrobial resistance in medical mycology

Author

Listed:
  • Neil A. R. Gow

    (University of Exeter, Geoffrey Pope Building)

  • Carolyn Johnson

    (Medical Research Council, Polaris House)

  • Judith Berman

    (Tel Aviv University)

  • Alix T. Coste

    (University Hospital Lausanne)

  • Christina A. Cuomo

    ((CAC) Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard)

  • David S. Perlin

    (Hackensack Meridian health)

  • Tihana Bicanic

    (St George’s University of London
    St George’s University Hospitals NHS Foundation Trust)

  • Thomas S. Harrison

    (University of Exeter, Geoffrey Pope Building
    St George’s University of London
    St George’s University Hospitals NHS Foundation Trust)

  • Nathan Wiederhold

    (University of Texas Health Science Center at San Antonio)

  • Mike Bromley

    (University of Manchester, CTF Building)

  • Tom Chiller

    (Center for Disease Control and Prevention Mycotic Disease Branch 1600 Clifton Rd, MSC-09)

  • Keegan Edgar

    (Center for Disease Control and Prevention Mycotic Disease Branch 1600 Clifton Rd, MSC-09)

Abstract

Prior to the SARS-CoV-2 pandemic, antibiotic resistance was listed as the major global health care priority. Some analyses, including the O’Neill report, have predicted that deaths due to drug-resistant bacterial infections may eclipse the total number of cancer deaths by 2050. Although fungal infections remain in the shadow of public awareness, total attributable annual deaths are similar to, or exceeds, global mortalities due to malaria, tuberculosis or HIV. The impact of fungal infections has been exacerbated by the steady rise of antifungal drug resistant strains and species which reflects the widespread use of antifungals for prophylaxis and therapy, and in the case of azole resistance in Aspergillus, has been linked to the widespread agricultural use of antifungals. This review, based on a workshop hosted by the Medical Research Council and the University of Exeter, illuminates the problem of antifungal resistance and suggests how this growing threat might be mitigated.

Suggested Citation

  • Neil A. R. Gow & Carolyn Johnson & Judith Berman & Alix T. Coste & Christina A. Cuomo & David S. Perlin & Tihana Bicanic & Thomas S. Harrison & Nathan Wiederhold & Mike Bromley & Tom Chiller & Keegan , 2022. "The importance of antimicrobial resistance in medical mycology," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-32249-5
    DOI: 10.1038/s41467-022-32249-5
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    References listed on IDEAS

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    1. Takanori Furukawa & Norman van Rhijn & Marcin Fraczek & Fabio Gsaller & Emma Davies & Paul Carr & Sara Gago & Rachael Fortune-Grant & Sayema Rahman & Jane Mabey Gilsenan & Emma Houlder & Caitlin H. Ko, 2020. "The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus," Nature Communications, Nature, vol. 11(1), pages 1-16, December.
    2. Ci Fu & Xiang Zhang & Amanda O. Veri & Kali R. Iyer & Emma Lash & Alice Xue & Huijuan Yan & Nicole M. Revie & Cassandra Wong & Zhen-Yuan Lin & Elizabeth J. Polvi & Sean D. Liston & Benjamin VanderSlui, 2021. "Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Jiaxin Gao & Haitao Wang & Zeyao Li & Ada Hang-Heng Wong & Yi-Zheng Wang & Yahui Guo & Xin Lin & Guisheng Zeng & Haoping Liu & Yue Wang & Jianbin Wang, 2018. "Candida albicans gains azole resistance by altering sphingolipid composition," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    4. Alexander Rosenberg & Iuliana V. Ene & Maayan Bibi & Shiri Zakin & Ella Shtifman Segal & Naomi Ziv & Alon M. Dahan & Arnaldo Lopes Colombo & Richard J. Bennett & Judith Berman, 2018. "Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia," Nature Communications, Nature, vol. 9(1), pages 1-14, December.
    5. Robert Zarnowski & Andrea Noll & Marc G. Chevrette & Hiram Sanchez & Ryley Jones & Hanna Anhalt & Jen Fossen & Anna Jaromin & Cameron Currie & Jeniel E. Nett & Aaron Mitchell & David R. Andes, 2021. "Coordination of fungal biofilm development by extracellular vesicle cargo," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    6. Mark Woolhouse & Jeremy Farrar, 2014. "Policy: An intergovernmental panel on antimicrobial resistance," Nature, Nature, vol. 509(7502), pages 555-557, May.
    7. Brian L. Wickes & Nathan P. Wiederhold, 2018. "Molecular diagnostics in medical mycology," Nature Communications, Nature, vol. 9(1), pages 1-13, December.
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