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A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans

Author

Listed:
  • Priya Jaitly

    (Jawaharlal Nehru Centre for Advanced Scientific Research)

  • Mélanie Legrand

    (Université Paris Cité, INRAE, USC2019, Unité Biologie et Pathogénicité Fongiques)

  • Abhijit Das

    (Jawaharlal Nehru Centre for Advanced Scientific Research)

  • Tejas Patel

    (Jawaharlal Nehru Centre for Advanced Scientific Research)

  • Murielle Chauvel

    (Université Paris Cité, INRAE, USC2019, Unité Biologie et Pathogénicité Fongiques)

  • Corinne Maufrais

    (Université Paris Cité, Bioinformatics and Biostatistics Hub)

  • Christophe d’Enfert

    (Université Paris Cité, INRAE, USC2019, Unité Biologie et Pathogénicité Fongiques)

  • Kaustuv Sanyal

    (Jawaharlal Nehru Centre for Advanced Scientific Research
    Osaka University)

Abstract

Chromosomal instability caused by cell division errors is associated with antifungal drug resistance in fungal pathogens. Here, we identify potential mechanisms underlying such instability by conducting an overexpression screen monitoring chromosomal stability in the human fungal pathogen Candida albicans. Analysis of ~1000 genes uncovers six chromosomal stability (CSA) genes, five of which are related to cell division genes of other organisms. The sixth gene, CSA6, appears to be present only in species belonging to the CUG-Ser clade, which includes C. albicans and other human fungal pathogens. The protein encoded by CSA6 localizes to the spindle pole bodies, is required for exit from mitosis, and induces a checkpoint-dependent metaphase arrest upon overexpression. Thus, Csa6 is an essential cell cycle progression factor that is restricted to the CUG-Ser fungal clade, and could therefore be explored as a potential antifungal target.

Suggested Citation

  • Priya Jaitly & Mélanie Legrand & Abhijit Das & Tejas Patel & Murielle Chauvel & Corinne Maufrais & Christophe d’Enfert & Kaustuv Sanyal, 2022. "A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-31980-3
    DOI: 10.1038/s41467-022-31980-3
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    References listed on IDEAS

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    1. Jeanne Ropars & Corinne Maufrais & Dorothée Diogo & Marina Marcet-Houben & Aurélie Perin & Natacha Sertour & Kevin Mosca & Emmanuelle Permal & Guillaume Laval & Christiane Bouchier & Laurence Ma & Kat, 2018. "Gene flow contributes to diversification of the major fungal pathogen Candida albicans," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    2. Davide Tamborrini & Maria Angeles Juanes & Sandy Ibanes & Giulia Rancati & Simonetta Piatti, 2018. "Recruitment of the mitotic exit network to yeast centrosomes couples septin displacement to actomyosin constriction," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    3. Shreyas Sridhar & Tetsuya Hori & Reiko Nakagawa & Tatsuo Fukagawa & Kaustuv Sanyal, 2021. "Bridgin connects the outer kinetochore to centromeric chromatin," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
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