IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v9y2018i1d10.1038_s41467-018-06767-0.html
   My bibliography  Save this article

Recruitment of the mitotic exit network to yeast centrosomes couples septin displacement to actomyosin constriction

Author

Listed:
  • Davide Tamborrini

    (Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM)
    Max-Planck-Institute of Molecular Physiology)

  • Maria Angeles Juanes

    (Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM)
    Brandeis University)

  • Sandy Ibanes

    (Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM))

  • Giulia Rancati

    (Institute of Medical Biology)

  • Simonetta Piatti

    (Centre de Recherche en Biologie Cellulaire de Montpellier (CRBM))

Abstract

In many eukaryotic organisms cytokinesis is driven by a contractile actomyosin ring (CAR) that guides membrane invagination. What triggers CAR constriction at a precise time of the cell cycle is a fundamental question. In budding yeast CAR is assembled via a septin scaffold at the division site. A Hippo-like kinase cascade, the Mitotic Exit Network (MEN), promotes mitotic exit and cytokinesis, but whether and how these two processes are independently controlled by MEN is poorly understood. Here we show that a critical function of MEN is to promote displacement of the septin ring from the division site, which in turn is essential for CAR constriction. This is independent of MEN control over mitotic exit and involves recruitment of MEN components to the spindle pole body (SPB). Ubiquitination of the SPB scaffold Nud1 inhibits MEN signaling at the end of mitosis and prevents septin ring splitting, thus silencing the cytokinetic machinery.

Suggested Citation

  • Davide Tamborrini & Maria Angeles Juanes & Sandy Ibanes & Giulia Rancati & Simonetta Piatti, 2018. "Recruitment of the mitotic exit network to yeast centrosomes couples septin displacement to actomyosin constriction," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06767-0
    DOI: 10.1038/s41467-018-06767-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-018-06767-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-018-06767-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Maritzaida Varela Salgado & Ingrid E. Adriaans & Sandra A. Touati & Sandy Ibanes & Joséphine Lai-Kee-Him & Aurélie Ancelin & Luca Cipelletti & Laura Picas & Simonetta Piatti, 2024. "Phosphorylation of the F-BAR protein Hof1 drives septin ring splitting in budding yeast," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Priya Jaitly & Mélanie Legrand & Abhijit Das & Tejas Patel & Murielle Chauvel & Corinne Maufrais & Christophe d’Enfert & Kaustuv Sanyal, 2022. "A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-06767-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.