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Gene flow contributes to diversification of the major fungal pathogen Candida albicans

Author

Listed:
  • Jeanne Ropars

    (Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
    Ecologie Systematique et Evolution, CNRS, Univ. Paris Sud, AgroParisTech, Université Paris Saclay)

  • Corinne Maufrais

    (Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
    Center for Bioinformatics, BioStatistics and Integrative Biology (C3BI), USR 3756 IP CNRS, Institut Pasteur)

  • Dorothée Diogo

    (Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA)

  • Marina Marcet-Houben

    (Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
    Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology
    Universitat Pompeu Fabra (UPF))

  • Aurélie Perin

    (Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA)

  • Natacha Sertour

    (Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA)

  • Kevin Mosca

    (Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA)

  • Emmanuelle Permal

    (Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA)

  • Guillaume Laval

    (Center for Bioinformatics, BioStatistics and Integrative Biology (C3BI), USR 3756 IP CNRS, Institut Pasteur
    UMR 2000 CNRS, Institut Pasteur)

  • Christiane Bouchier

    (Biomics Pole, CITECH, Institut Pasteur)

  • Laurence Ma

    (Biomics Pole, CITECH, Institut Pasteur)

  • Katja Schwartz

    (Stanford University Medical School)

  • Kerstin Voelz

    (School of Biosciences and Institute of Microbiology and Infection, University of Birmingham)

  • Robin C. May

    (School of Biosciences and Institute of Microbiology and Infection, University of Birmingham)

  • Julie Poulain

    (CEA, Genoscope, Institut de biologie François Jacob
    CNRS UMR 8030
    Univ. Evry, Univ. Paris-Saclay)

  • Christophe Battail

    (CEA, Genoscope, Institut de biologie François Jacob)

  • Patrick Wincker

    (CEA, Genoscope, Institut de biologie François Jacob
    CNRS UMR 8030
    Univ. Evry, Univ. Paris-Saclay)

  • Andrew M. Borman

    (UK National Mycology Reference Laboratory, Public Health England)

  • Anuradha Chowdhary

    (Vallabhbhai Patel Chest Institute, University of Delhi)

  • Shangrong Fan

    (Peking University Shenzhen Hospital)

  • Soo Hyun Kim

    (Chonnam National University Medical School)

  • Patrice Pape

    (EA1155 – IICiMed, Institut de Recherche en Santé 2, Université de Nantes)

  • Orazio Romeo

    (University of Messina
    IRCCS – Centro Neurolesi Bonino-Pulejo)

  • Jong Hee Shin

    (Chonnam National University Medical School)

  • Toni Gabaldon

    (Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology
    Universitat Pompeu Fabra (UPF)
    ICREA)

  • Gavin Sherlock

    (Stanford University Medical School)

  • Marie-Elisabeth Bougnoux

    (Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA
    Unité de Parasitologie-Mycologie, Service de Microbiologie clinique, Hôpital Necker-Enfants-Malades, Assistance Publique des Hôpitaux de Paris (APHP)
    Université Paris Descartes, Sorbonne Paris-Cité)

  • Christophe d’Enfert

    (Fungal Biology and Pathogenicity Unit, Institut Pasteur, INRA)

Abstract

Elucidating population structure and levels of genetic diversity and recombination is necessary to understand the evolution and adaptation of species. Candida albicans is the second most frequent agent of human fungal infections worldwide, causing high-mortality rates. Here we present the genomic sequences of 182 C. albicans isolates collected worldwide, including commensal isolates, as well as ones responsible for superficial and invasive infections, constituting the largest dataset to date for this major fungal pathogen. Although, C. albicans shows a predominantly clonal population structure, we find evidence of gene flow between previously known and newly identified genetic clusters, supporting the occurrence of (para)sexuality in nature. A highly clonal lineage, which experimentally shows reduced fitness, has undergone pseudogenization in genes required for virulence and morphogenesis, which may explain its niche restriction. Candida albicans thus takes advantage of both clonality and gene flow to diversify.

Suggested Citation

  • Jeanne Ropars & Corinne Maufrais & Dorothée Diogo & Marina Marcet-Houben & Aurélie Perin & Natacha Sertour & Kevin Mosca & Emmanuelle Permal & Guillaume Laval & Christiane Bouchier & Laurence Ma & Kat, 2018. "Gene flow contributes to diversification of the major fungal pathogen Candida albicans," Nature Communications, Nature, vol. 9(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-04787-4
    DOI: 10.1038/s41467-018-04787-4
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    Cited by:

    1. Priya Jaitly & Mélanie Legrand & Abhijit Das & Tejas Patel & Murielle Chauvel & Corinne Maufrais & Christophe d’Enfert & Kaustuv Sanyal, 2022. "A phylogenetically-restricted essential cell cycle progression factor in the human pathogen Candida albicans," Nature Communications, Nature, vol. 13(1), pages 1-18, December.

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